不同剂量右美托咪定对妇科腹腔镜手术患者围术期炎症因子和术后认知功能的影响  被引量:16

Influence of different doses of dexmedetomidine on inflammatory factor in perioperative period and postoperative cognitive function of patients receiving gynecological laparoscopic operation

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作  者:崔敏[1] 司纪国 盖长新 

机构地区:[1]山东省淄博市妇幼保健院麻醉科,山东淄博255000 [2]山东省淄博市中心医院麻醉科,山东淄博255000

出  处:《中国当代医药》2015年第30期53-55,共3页China Modern Medicine

摘  要:目的:探讨不同剂量右美托咪定对妇科腹腔镜手术患者围术期炎症因子和术后认知功能的影响。方法选取本院2014年2月~2015年1月收治的200例妇科腹腔镜手术患者作为研究对象,根据右美托咪定的使用剂量将其分为A组(70例)、B组(70例)和C组(60例)。A组、B组和C组分别给予静脉输注0.8μg/(kg·h)、0.4μg/(kg·h)和等量生理盐水,比较3组围术期的炎症因子水平和术后认知功能情况。结果A组t2时刻的TNF-α、CRP、IL-6、IL-10水平显著低于B组和C组,差异有统计学意义(P〈0.05)。 B组t2时刻的TNF-α、CRP、IL-6、IL-10水平显著低于C组,差异有统计学意义(P〈0.05)。A组术后1 d的MMSE评分显著高于B组和C组,TMT完成时间显著短于B组和C组,差异有统计学意义(P〈0.05)。 B组术后1 d的MMSE评分显著高于C组,TMT完成时间显著短于C组,差异有统计学意义(P〈0.05)。结论高剂量右美托咪定能够降低妇科腹腔镜手术患者围术期的炎症因子水平,术后认知功能更佳,值得临床推广应用。Objective To discuss the influence of different doses of dexmedetomidine on inflammatory factor in periop-erative period and postoperative cognitive function of patients receiving gynecological laparoscopic operation. Methods 200 patients receiving gynecological laparoscopic operation in our hospital from February 2014 to January 2015 were selected and divided into group A (70 cases),group B (70 cases) and group C (60 cases) according to the dose of dexmedetomidin.Group A,B and C was administered with 0.8 μg/(kg·h) dexmedetomidine,0.4 μg/(kg·h) dexmedetomi-dine and equivalent normal saline respectively.The inflammatory factor in perioperative period and postoperative cogni-tive function of patients among three groups was compared respectively. Results The level of TNF-α,CRP,IL-6,IL-10 at t2 moment in group A was lower than that in group B and group C,with significant difference (P〈0.05).The level of TNF-α,CRP,IL-6,IL-10 at t2 moment in group B was lower than that in group C,with significant difference (P〈0.05). The MMSE score of after operation at 1 d in group A was higher than that in group B and group C,TMT completion time after operation at 1 d in group A was shorter than that in group B and group C,with significant difference (P〈0.05). The MMSE score of after operation at 1 d in group B was higher than that in group C,TMT completion time after opera-tion at 1 d in group B was shorter than that in group C,with significant difference (P〈0.05). Conclusion High dose dexmedetomidine can reduce the level of inflammatory factor in perioperative period of patients receiving gynecological laparoscopic surgery,and postoperative cognitive function is better,it is worthy of promotion and application.

关 键 词:右美托咪定 妇科腹腔镜手术 围术期 炎症因子 术后认知功能 

分 类 号:R614[医药卫生—麻醉学]

 

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