雌激素及其受体在青少年特发性脊柱侧凸发病中作用的研究进展  

RESEARCH PROGRESS OF ROLE OF ESTROGEN AND ESTROGEN RECEPTOR ON ONSET AND PROGRESSION OF ADOLESCENT IDIOPATHIC SCOLIOSIS

作　　者：周传坤[1] 王欢[1] 邹银双 方煌[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院骨科,武汉430030

出　　处：《中国修复重建外科杂志》2015年第11期1441-1445,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(81271347)~~

摘　　要：目的综述近年雌激素及其受体在青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)发病中作用的研究进展。方法广泛查阅国内外与AIS病因中雌激素及其受体异常相关的临床资料与基础研究,并进行总结分析。结果大多数AIS患者体内存在雌激素及其受体异常,主要包括血清雌激素水平升高、细胞对雌激素反应性异常、月经初潮年龄延迟及核受体与膜受体基因多态性,而且与侧凸的易感性、严重程度和进展风险密切相关。结论雌激素及其受体通过不同病理机制在一定程度上参与了AIS的发生、发展,但机制尚不明确,仍有待进一步研究。Objective To review the recent progress in research on the role of estrogen and estrogen receptor on the onset and progression of adolescent idiopathic scoliosis（AIS）. Methods The recently published clinical and experimental 1iterature at home and abroad on abnormality of estrogen and its receptor in AIS was reviewed and summarized. Results There are many abnormal changes of estrogen and estrogen receptor in most AIS patients, including higher serum estrogen concentration, unusual cellular response to estrogen, late age at menarche, and gene polymorphisms of estrogen receptor, which are closely associated with AIS predisposition, curve severity, and scoliosis progression. Conclusion Estrogen and its receptor participate in the onset and progression of AIS by certain mechanisms, but exact mechanism remains indefinite, which needs further research to better define the role of estrogen and its receptor in AIS.

关 键 词：青少年特发性脊柱侧凸 雌激素 月经初潮年龄 基因多态性 

分 类 号：R682.3[医药卫生—骨科学]