高压氧联合厄贝沙坦预防2型糖尿病患者微血管病变的临床效果  

Clinical effect of hyperbaric oxygen combined with irbesartan in prevention of type 2 diabetes mellitus with microangiopathy

作　　者：马丽芬[1] 刘彦君[2] 苏振丽[1] 郑瑜[1] 

机构地区：[1]宝鸡市中心医院内分泌科,陕西宝鸡721008 [2]解放军第三医院内分泌科,陕西宝鸡721004

出　　处：《中国医学前沿杂志（电子版）》2015年第9期29-32,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探讨高压氧联合厄贝沙坦预防2型糖尿病患者微血管病变的临床效果。方法选取本院2009年4月至2011年4月诊断为2型糖尿病患者120例为研究对象,采用区组随机方法分为对照组和观察组。对照组患者给予高压氧干预,1次/天,10天为一疗程,连续3个疗程;观察组患者在对照组基础上口服厄贝沙坦,150 mg/次,1次/天,10天为一疗程,连续服用3个疗程。两组患者均给予同等降糖药物治疗。随访3年,观察比较两组患者微血管病变及血糖情况。结果随时间延长,两组患者空腹血糖(FPG)、餐后2小时血糖(2h PG)、糖化血红蛋白(Hb A1c)水平逐渐下降,且观察组下降趋势更明显(P<0.05);观察组患者尿微量清蛋白排泄率(urinary albumin excreting rate,UAER)基本处于平稳状态,对照组患者UAER上升速度明显快于观察组(P<0.05);对照组患者踝-肱指数(ankle-brachial index,ABI)下降速度快于观察组(P<0.05);观察组患者出现1例Ⅰ期和1例Ⅱ期视网膜病变,对照组患者出现5例Ⅰ期、3例Ⅱ期和1例Ⅲ期视网膜病变(χ2=4.90,P<0.05)。结论高压氧联合厄贝沙坦能够更好地预防2型糖尿病患者微血管病变的发生。ObjectiveTo explore the clinical effect of hyperbaric oxygen combined with irbesartan in prevention of type 2 diabetes mellitus with microangiopathy.MethodSelected 120 patients diagnosed type 2 diabetic mellitus in our hospital from April 2009 to April 2011 as research objects, they were randomly divided into control group and observation group. Patients in control group were treated with hyperbaric oxygen intervention, once a day, 10 days for a course of treatment, completed 3 course. Patients in observation group were given irbesartan orally on the basis of control group, 150 mg/times, 1 times/day, 10 days for a course of treatment, completed 3 courses, also the two groups were given equal antidiabetic drug treatment. Followed up for 3 years, microangiopathy and blood glucose were compared between the two groups.ResultFPG, HbA1c, 2hPG levels of the two groups gradually decreased, and the downward trend of observation group was more obvious （P〈0.05）; UAER of observation group was basically in a stable state, UAER of control group increased faster than observation group （P〈0.05）; ABI of control group decreased faster than observation group （P〈0.05）; in observation group, there were 1 case of stageⅠ and 1 case of stageⅡ retinopathy, and in control group, there were 5 cases of stageⅠ, 3 cases of stageⅡand 1 case of stageⅢ retinopathy （χ^2=4.90,P〈0.05）.ConclusionHyperbaric oxygen combined with irbesartan can better prevent occurrence of type 2 diabetic patients with microangiopathy.

关 键 词：厄贝沙坦 高压氧 2型糖尿病 微血管病变 

分 类 号：R587.2[医药卫生—内分泌]