针对有机磷农药对乙酰胆碱酯酶活性的抑制作用研究  

Inhibitory Effects of Organophosphorus Pesticides on Acetylcholinesterase Activity

作　　者：杨卫[1] 朱蕴玲[1] 展小红[1] 张文青[1] 王丹[1] 

机构地区：[1]靖江市人民医院,江苏靖江214500

出　　处：《中外医学研究》2015年第31期20-21,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:对有机磷农药对乙酰胆碱酯酶活性的抑制作用进行探讨。方法:选取2010年1月-2014年12月在笔者所在医院治疗的100例有机磷农药中毒患者,分别对患者中毒后1、24、48、72、120 h及治愈后的乙酰胆碱酯酶活性进行检测,比较患者中毒后与治愈后的乙酰胆碱酯酶活性,进行对照分析。结果:中毒后1、24、48、72、120 h患者血液中乙酰胆碱酯酶活性明显低于治愈后,差异有统计学意义(P<0.05)。100例中毒患者在抢救治疗后,死亡率为13.00%,剩余患者转到相关科室或转院继续进行治疗。结论:急性有机磷中毒后,大大抑制患者的乙酰胆碱酯酶活性,导致乙酰胆碱酶在患者脑组织大量累积,严重影响患者的预后,因此需及时给予患者有效处理,缓解患者神经组织受到的损伤,保证患者脑组织的完整性。Objective：To explore the inhibitory effects of organophosphorus pesticides on acetylcholinesterase activity.Method：In our hospital from January 2010 to December 2014 100 cases of organophosphorus pesticide poisoning patients were selected.For patients with after poisoning respectively 1,24,48,72,120 h and acetylcholinesterase activity were detected after cure.Comparison of patients cured after poisoning and acetylcholinesterase activity were analyzed.Result：1,24,48,72,120 h acetylcholinesterase in the blood of patients were significantly lower than that of the activity after poisoning after cure,there were significant difference（P〈0.05）.100 cases of poisoning patients in the emergency treatment,the mortality rate was 13%,the remaining patients transferred to the relevant department or hospital to continue treatment.Conclusion：Acute organophosphate poisoning patients,greatly inhibited acetylcholinesterase activity,leading to acetylcholine accumulation in brain tissue of patients,seriously affect the prognosis of patients,patients need timely effective treatment therefore,alleviate nerve tissue of patients with trauma,ensure completeness of patients with brain tissue.

关 键 词：有机磷农药 乙酰胆碱酯酶活性 抑制作用 

分 类 号：R595.4[医药卫生—内科学]