功能磁共振用于肿瘤光热和光动力协同治疗的实时监测研究  

Real-time monitoring of tumor response to photothermal/photodynamic therapy by functional magnetic resonance imaging

作　　者：曹健波 付贵峰[1] 张帆[1] 刘刚[1] 

机构地区：[1]厦门大学公共卫生学院分子影像暨转化医学研究中心,福建厦门361102

出　　处：《福州大学学报（自然科学版）》2015年第5期722-726,共5页Journal of Fuzhou University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(81201086;81471655)

摘　　要：将实验动物分为光热治疗组、光动力治疗组、光热和光动力协同治疗组,使用T2加权和扩散加权两种磁共振成像方式对治疗效果进行实时监测,并使用病理学方法对磁共振检测效果进行验证.实验结果发现,两个单纯治疗组中肿瘤并未被完全杀灭;而协同治疗组中,肿瘤被完全杀灭.磁共振作为无创监测手段,在疗效评价中有巨大的应用价值,并可对纳米粒子的设计合成起到指导作用.This paper assess the long -term curative effect of tumor after different treatment strategies . Compared with photodynamic therapy or photothermal therapy alone , the combined therapy showed a significantly synergistic effect , which was demonstrated by functional MRI .The results provide a di-rect, non-invasive method for in vivo monitoring of the treatment response to nanoparticle -mediated PTT, which can be used to guide cancer therapy to improve potential clinical outcomes .

关 键 词：功能磁共振 光热治疗 光动力治疗 实时监测 

分 类 号：R445.2[医药卫生—影像医学与核医学]