0～2岁试管婴儿体格及精神运动发育情况分析  

Analysis on physical and psychomotor development of test- tube babies under two years

作　　者：许小艳[1] 姜艳[1] 杨景晖[1] 麻新梅[1] 刘凯[1] 米弘瑛[1] 李利[1] 

机构地区：[1]云南省第一人民医院儿科,云南昆明650032

出　　处：《中国妇幼保健》2015年第32期5566-5570,共5页Maternal and Child Health Care of China

基　　金：云南省应用基础研究项目〔2010ZC213〕

摘　　要：目的探讨试管婴儿（IVF／ICSI）0～2岁的体格及精神运动发育与自然受孕儿（NC）有无差异。方法2010年10月～2011年10月在云南省第一人民医院产科出生且0～2岁在儿科随访的试管婴儿共100例（双胎68例、单胎32例），随机抽取同期在产科出生且0～2岁在儿科随访的自然受孕（Natureconceive，NC）双胎47例、单胎53例（共100例）作为对照，按单胎和双胎分别比较IVF／ICSI与NC出生时情况、体格发育及精神运动发育情况。结果①IVF／ICSI单胎母亲生产年龄（31．19±4．87）岁、比Nc单胎（30．12±4．18）岁、大（x2=3．659，P〈0．01），IVF／ICSI双胎低出生体重发生率、6月年龄别体重、1岁时年龄别身高发育迟缓率高于NC双胎（P〈O．05），但其余出生时情况及体格发育IVF／ICSI无论单胎及双胎与NC比较差异均无统计学意义。②IVF／ICSI单胎及双胎精神运动发育与NC比较差异均无统计学意义。③多因素分析发现父母文化程度对MDI及PDI均有影响，且呈正相关，低出生体重对PDI亦有影响，但呈负相关。结论①试管婴儿单胎与自然受孕儿单胎0～2岁的体格发育无差别，试管婴儿双胎低出生体重发生率高于自然受孕双胎儿，可能与试管婴儿母亲生产年龄大有关，而低出生体重可能影响婴幼儿1岁以前的体格发育。②试管婴儿无论单胎及双胎与自然受孕儿0～2岁精神运动发育没有差别，精神运动发育受父母文化程度及出生体重的影响。Objective To explore the differences of physical and psychomotor development between test-tube babies after in vitro fertifization/intracytoplasmic sperm injection （IVF/ICSI） and babies of nature conceiving under two years. Methods One hundred test- tube babies （68 twins and 32 singletons） under two years born in Department of Pediatrics in the hospital from October 2010 to October 2011 were selected as IVF/ICSI group and followed up, 100 babies of nature conceiving （47 twins and 53 singletons） under two years born in De- partment of Pediatrics in the hospital during the same period were randomly selected as control group; the birth situations, physical and psy- chomotor development of babies in IVF/ICSI group and control group were compared respectively according to twin and singleton. Results The age of delivery of singletons in IVF/ICSI group was （31.19±4. 87） years old, which was statistically significantly older than that in control group [ （30. 12±4. 18 ） years old] （X2 = 3. 659, P〈0.01 ） ; the incidence rate of low birth weight, weight for age at 6 months, height for age at one year, the incidence rate of developmental delay among twins in IVF/ICSI group were statistically significantly higher than those in control group （ P〈O. 05 ）, but there was no statistically significant difference in the incidence rates of other neonatal out- come and physical development of singletons and twins between the two groups. There was no statistically significant difference in psychomo- tor development of singletons and twins between the two groups. Multivariate analysis showed that parental educational levels had impacts on MDI and PDI, there were positive correlations, low birth weight also had impact on PDI, but there was a negative correlation. Conclusion There was no significant difference in physical development between singletons of test-tube babies and singletons of nature conceiving under two years, the incidence rate of low birth weight among twins of test-tube babies was higher

关 键 词：体外受精-胚胎移植 单精子卵胞浆内注射 生长发育 精神运动发育 儿童 

分 类 号：R722[医药卫生—儿科]