血清视黄醇结合蛋白4与慢性阻塞性肺疾病相关性研究  

Association between serum RBP4 and chronic obstructive pulmonary diseases

作　　者：龙虹羽[1] 庞才双[1] 文富强[1] 

机构地区：[1]四川大学华西医院呼吸内科人类疾病生物治疗国家重点实验室呼吸病学研究室,成都610041

出　　处：《中国实用内科杂志》2015年第11期938-940,共3页Chinese Journal of Practical Internal Medicine

基　　金：国家科技支撑计划-慢性阻塞性肺疾病及呼吸困难的规范化诊断治疗评价与推广研究(2014BAI08B04)

摘　　要：目的探讨视黄醇结合蛋白(RBP)4在慢性阻塞性肺疾病(慢阻肺)血清中的表达及其和炎症反应、氧化应激的关系。方法用酶联免疫吸附法(ELISA)测定四川大学华西医院2014年6—12月97例慢阻肺患者和47例对照者血清RBP4浓度,应用液相芯片技术测定两组C反应蛋白(CRP)、髓过氧化物酶(MPO)浓度,并测定肺功能指标。分析RBP4浓度在两组的差异,观察其与CRP、MPO、肺功能指标的关系。结果慢阻肺组血清RPP4表达明显高于对照组[(78.33±30.13)mg/L对(51.55±17.92)mg/L,P<0.05]。RBP4的表达与CRP的表达正相关(r=0.432,P<0.001),与MPO的表达正相关(r=0.338,P<0.001),与第一秒用力呼气容积占预计值百分比(FEV1%)呈负相关(r=-0.263,P=0.001),与FEV1占用力肺活量(FVC)百分比呈负相关(r=-0.339,P<0.001)。结论慢阻肺患者血清RBP4表达和肺功能有密切关系。氧化应激、炎症反应可能会导致RBP4表达上升。Objective To investigate the level of serum retinol binding protein 4（RBP4） in patients with chronic obstructive pulmonary disease（COPD） and its association with inflammation and oxidative stress. Methods Te level of serum RBP4 was measured with enzyme-linked immunosorbent assay and the levels of serum C-reactive protein（CRP） and myeloperoxidase（MPO） were measured with Luminex liquid chip technology in COPD patients（n = 97） and control subjects（n = 47）. The correlations of the RBP4 level with lung function（FEV1% pred, FEV1/FVC）, the CRP level, and the MPO level were analyzed with Person correlation analysis. Results The level of RBP4 was significantly higher in the COPD group than that in the control group [（78.33±30.13） mg/L vs.（51.55± 17.92） mg/L, P〈0.05）]. The level of RBP4 was correlated positively with CRP（r = 0.432, P〈0.001） and MPO（r = 0.338, P〈0.001）. Conversely, the level of RBP4 was correlated negatively with lung function, based on FEV1% predicated（r =-0.263 P = 0.001） and FEV1/FVC%（r =-0.339, P〈0.001）. Conclusion The level of serum RBP4 is significantly higher in COPD patients than that in healthy controls and closely associated with lung function, inflammatory reaction and oxidative stress.

关 键 词：视黄醇结合蛋白4 慢性阻塞性肺疾病 肺功能 C反应蛋白 髓过氧化物酶 

分 类 号：R562[医药卫生—呼吸系统]