华法林抗凝过程中不良反应及其影响因素分析  

Adverse reaction in warfarin anticoagulation and influence factors

作　　者：喻婉莹[1] 项玉霞[2] 阳国平[1,2] 

机构地区：[1]中南大学药学院,长沙410013 [2]中南大学湘雅三医院,长沙410013

出　　处：《中南药学》2015年第10期1058-1061,共4页Central South Pharmacy

基　　金：科技部国际科技合作与交流专项(No.2014DFA30900)

摘　　要：华法林(warfarin)是临床上最常用的口服抗凝血药,用于治疗和预防各种血栓栓塞性疾病。华法林治疗窗窄,个体差异大,因而剂量要求各有不同,并且用药不足会达不到抗凝效果,而用药过量又会增加出血风险。华法林相关不良事件中最常见的即为出血反应。本文汇总了近年来关于华法林出血性研究,分析了影响出血的相关因素以及其作用机制,期望能为临床安全使用华法林进行抗凝治疗提供参考。Warfarin is the most widely used oral anticoagulant in clinical use today. It is used for the prevention and treatment of thromboembolic events in patients. Warfarin has a narrow therapeutic range and widespread interindividual variation, so the dose requirements are different. Dose shortage may not show the anticoagulant effect, but overdose may increase the risk of bleeding, which is the most common adverse events. This review summarizes the recent re- search on wafarin complications, analyzes the influence factors of hemorrhage and its mechanism, and hopes to provide a reference for safe clinical use of wafarin anticoagulant.

关 键 词：口服抗凝药 华法林 出血反应 影响因素 

分 类 号：R453[医药卫生—治疗学]