妊娠期间口服二甲双胍对子代生长发育影响的随访观察  

Effect of Metformin Used during Pregnancy on Subsequent Growth Development on Their Children

作　　者：王蕴慧[1] 李玲[2] 梁立阳[1] 蓝海英 张睿[1] 陈慧[1] 谭剑平[1] 

机构地区：[1]中山大学孙逸仙纪念医院,广东广州510120 [2]河南省肿瘤医院,河南郑州450003 [3]广东省广州市越秀区妇幼保健院,广东广州510030

出　　处：《实用妇产科杂志》2015年第11期848-851,共4页Journal of Practical Obstetrics and Gynecology

基　　金：广东省科技计划项目(编号:2009B030801157)

摘　　要：目的:观察孕期口服二甲双胍对子代生长发育的影响。方法:妊娠期在中山大学孙逸仙纪念医院就诊并口服二甲双胍治疗的母亲所分娩的婴幼儿137例为二甲双胍组,广州市越秀区妇幼保健院定期儿科保健的相应年龄健康婴幼儿931例为健康对照组,分别收集两组婴幼儿6个月、1周岁、18个月、2周岁、3周岁、4周岁、5周岁的生长指标(身长及体重值),以及精神智力发育情况。结果:两组婴幼儿6个月、1周岁、18个月、2周岁、3周岁、4周岁、5周岁的身高值及体重值相比差异均无统计学意义(P>0.05)。二甲双胍组婴幼儿精神、智力发育未见明显异常。结论:孕期服用二甲双胍对后代生长发育无明显不良影响。Objective：the growth and development of the children whose mothers were treated mefformin during pregnancy was observed to assess the safety of mefformin during pregnancy. Methods：Follow-up survey for 137children whose mothers had received metformin during pregnancy was carried out. The body height and body weight of the children whose mothers had received mefformin during pregnancy were compared with that of the same age normal children＇s whose mothers were healthy and without any pregnancy complications. We collected data of children＇s body height and body weight when they were 6 months of age,one-year-old, 18 months of age, two-year-old,three-year-old, four-year-old, five-year-old, reapectively. Results. There were no significant differences about the body height and body weight of the children whose mothers were treated metformin during pregnancy compared with normal children＇s when they were 6 months of age, one-year-old, 18 months of age, two-year-old, three-year-old, four-year-old, five-year-old, respectively （ P 〉 0. 05 ）. Conclusions： Metformin treatment during pregnancy appears to have no adverse effects on the growth and development of children.

关 键 词：二甲双胍 妊娠期 子代生长发育 

分 类 号：R714.5[医药卫生—妇产科学]