^(18)F-FDG PET/CT显像脾脏弥漫代谢增高原因分析  

Reason analysis of diffuse increased splenic FDG uptake on ^(18)F-FDG PET/CT

作　　者：赵梅莘[1] 毛远[1] 张卫方[1] 张燕燕[1] 

机构地区：[1]北京大学第三医院核医学科,北京100191

出　　处：《中国医学影像技术》2015年第11期1716-1719,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨18F-FDG PET/CT显像中脾脏摄取弥漫性增高的原因。方法以脾脏弥漫性摄取高于肝脏为研究纳入标准,脾脏SUVmax/肝脏SUVmax>1为定量指标,共纳入36例患者,结合手术病理、出院诊断及随访结果,分析患者疾病构成情况。结果 36例脾脏摄取弥漫性增高的患者中,15例淋巴瘤、3例结核、9例其他感染性疾病、1例大动脉炎、1例系统性红斑狼疮,1例自身免疫性溶血性贫血,2例特发性血小板减少性紫癜,1例结节病、3例实体肿瘤(其中2例正在接受粒细胞集落刺激因子治疗)。结论 PET/CT显像中脾脏弥漫性代谢增高的现象,在淋巴瘤、结核及其他炎症状态、贫血、结节病、正在接受粒细胞集落刺激因子的患者中均可以出现,并不是某一类疾病的特征性表现。Objective To explore the reason for intense splenic uptake in patients with diffuse increased splenic FDG uptake on 18F-FDG PET/CT.Methods A retrospective review identified patients with diffuse increased splenic FDG uptake greater than hepatic activity.The SUVmaxfor the liver and spleen were measured and then the spleen/liver ratio（S/L ratio）was calculated.Finally 36 patients with S/L ratio above 1were included into analysis.The final diagnosis was established based on pathological biopsy,discharge diagnosis and long term follow up.The disease composition was analyzed.Results According to final diagnosis,36 patients with diffuse increased splenic FDG uptake,included 15 with lymphoma,3with tuberculosis,9with other infectious diseases,1with takayasu arteritis,1with systemic lupus erythematosus,1with autoimmune hemolytic anemia,2with idiopathic thrombocytopenic purpura,1with sarcoidosis and 3with solid tumors.In the patients with solid tumors,2were receiving treatment of granulocyte colony-stimulating facter（G-CSF）.Conclusion Diffused increased splenic uptake on ^18F-FDG PET/CT may appear in patients with lymphoma,tuberculosis or other inflammatory diseases,anemia,sarcoidosis and patient who is receiving treatment of G-CSF.It is not a characteristic feature of any specific disease.

关 键 词：体层摄影术 发射型计算机 单光子 18F氟脱氧葡萄糖 脾脏 代谢增高 

分 类 号：R817[医药卫生—影像医学与核医学] R657.6[医药卫生—放射医学]