慢性坏死性肺曲霉病3例报道并文献复习  

A report of 3 cases of chronic necrotizing pulmonary aspergillosis with review of literature

作　　者：卢鑫[1] 武良权[1] 文昱婷[1] 施毅[2] 张秀伟[1] 

机构地区：[1]南京医科大学附属江宁医院呼吸内科,211100 [2]南京军区南京总医院呼吸与危重症医学科,210002

出　　处：《国际呼吸杂志》2015年第21期1630-1633,共4页International Journal of Respiration

摘　　要：目的探索慢性坏死性肺曲霉病（CNPA）的临床特点。方法报道3例CNPA病例并对相关文献进行复习。结果CNPA是一种少见的肺曲霉病，临床表现缺乏特异性，常见的症状为咳嗽、咳痰和咯血。典型的肺部影像学检查显示为实变和结节。病理可见肺组织内曲霉菌丝侵袭、组织坏死和肉芽肿形成。结论CNPA的临床表现和影像学改变非常复杂，在诊断中需要综合患者的各种临床资料，包括临床症状、放射学、血清学检查及病理，一旦诊断需要立即给予系统性的抗真菌治疗。Objective To study the clinical feature of chronic necrotizing pulmonary aspergillosis. Methods three cases of CNPA were reported and the related data of CNPA were reviewed. Results CNPA was a rare form of pulmonary aspergillosis. Patients with CNPA usually had no specific clinical syndrome. On chest CT scans, it presented flake shadow or nodular. The histological feature of CNPA included the presence of tissue invasion by aspergillosis,tissue necrosis and granulomatous inflammation. Conclusions The clinical syndrome and radiological of CNPA are very complex. Its diagnosis requires the information of all relevant clinical data of the patients,including syndrnme, radiological, serumal test and pathological data. Treatment with antifungal medications is indicated once the diagnosis is made.

关 键 词：慢性坏死性肺曲霉病 诊断 治疗 

分 类 号：R587.2[医药卫生—内分泌]