中药毒代动力学研究进展  

Progress in toxicokinetics research of traditional Chinese medicines

作　　者：高方圆[1] 袁伯俊[1] 马秀娟[1] 夏振娜[1] 陆国才[1] 

机构地区：[1]第二军医大学药物安全性评价中心,上海200433

出　　处：《中国新药杂志》2015年第21期2448-2452,2458,共6页Chinese Journal of New Drugs

摘　　要：中药尤其是复方中药的效毒物质基础多元、复杂,难以明确甚至不明,因此中毒现象时有发生。中药毒代动力学作为中药安全性评价研究中的重要部分,能够有效解释毒性试验结果和预测人体安全性,是连接毒理试验现象和人用中药可能发生的不良反应评价之间的桥梁。但目前中药毒代动力学发展缓慢,存在许多瓶颈问题。解决中药毒代动力学的发展障碍,明确其效毒物质基础是关键。本文从中药毒代动力学的研究目的及意义、研究方法、困难与挑战和解决方法四方面进行了综述。Toxicity events of traditional Chinese medicines（ TCMs） frequently occur owing to the fact that the effective / toxic material bases of TCMs and Chinese herbal compounds are multiple,complex,and difficult to be understood or even unknown. TCM toxicokinetics,as an important part of evaluation of TCMs safety,can effectively explain the toxicity test results,predict medication safety in human and bridge the toxicological phenomena and adverse drug reactions of TCMs. But,the development of TCM toxicokinetics is slow and many bottlenecks are present. To overcome the obstacles to the development of TCM toxicokinetics,the key is to clarify the effective / toxic material base. This paper reviews the purposes and significance,methods,difficulties and challenges and solutions of TCM toxicokinetic research.

关 键 词：中药 毒代动力学研究 毒性机制 转化医学 

分 类 号：R932[医药卫生—生药学] R994.1[医药卫生—药学]