2型糖尿病合并脑病中医证候的数据挖掘  

Study on TCM syndromes of Type 2 diabetic encephalopathy by data mining

作　　者：龚燕冰[1] 倪青[2] 高思华[3] 罗增刚 易丹辉[5] 王永炎[6] 

机构地区：[1]北京中医药大学东方医院党院办,100078 [2]中国中医科学院广安门医院内分泌科,北京100053 [3]北京中医药大学,100029 [4]北京市中医药管理局,100026 [5]中国人民大学统计学院,北京100086 [6]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《国际中医中药杂志》2015年第11期1024-1027,共4页International Journal of Traditional Chinese Medicine

基　　金：国家自然基金面上资助课题（90209012）;国家科委科技基础工作专项基金（2001Dea20010）

摘　　要：目的：探讨2型糖尿病合并脑病的中医证候要素、靶位，以及理化指标与中医证候之间的关系。方法收集中国中医科学院广安门医院，北京中医药大学东直门医院、东方医院等九家医院约3年的2501例2型糖尿病患者的相关数据。对原始资料进行双人双机 epidata 录入，建立 Excel 数据库，选取342例2型糖尿病合并脑病患者的病历，采用因子分析和贝叶斯网络的方法进行数据挖掘。结果通过因子分析得出20个特征根大于1的因素，占总特征根的68.4%，其中5个因素属阴虚、5个因素属血瘀；通过贝叶斯网络得出空腹血糖异常者主要症状是倦怠乏力、气短懒言、大便频多；餐后2小时血糖异常者主要症状倦怠乏力、半身不遂；糖化血红蛋白异常者主要症状倦怠乏力、五心烦热、大便频多、夜尿频多。结论糖尿病合并脑病的证候要素是阴虚、血瘀；主要靶位是肝、肾、脾。空腹血糖异常者中医证候以气虚为主；餐后2 h 血糖异常患者的中医证候是气虚或风中脉络；糖化血红蛋白异常的患者，中医证型以气虚、阴虚常见。Objective To explore characteristics of the elements of syndrome, the disease position and the relationship between chemical indicators and TCM syndromes of type 2 diabetic encephalopathy. Methods 2 501 cases of type 2 diabetes clinical data were collected from Guang＇anmen Hospital of China Academy of Chinese Medical Sciences, Beijing University of Chinese Medicine, Dongzhimen Hospital, Dongfang Hospital, etc. in nearly 3 years, among which, 342 cases were type 2 diabetic encephalopathy. The original clinical data were double entried in epidata by two people, establishment forms in excel, factor analysis and Bayesian networks were used as data mining research methods. Results 20 elements which characteristic root more than 1 were derived by factor analysis, 68.4% were covered. Of all 20 elements, five factors belong to Yin, five factors belong to blood stasis; lassitude, shortness of breath, stool frequency were appeared when fasting glucose abnormalities; lassitude, hemiplegia were appeared when 2-hour postprandial blood glucose abnormalities;lassitude, feverish palms and soles, stool frequency, more nocturnal enuresis when glycated hemoglobin abnormalities by Bayesian networks. Conclusion The Elements of the syndrome of type 2 diabetes encephalopathy were deficiency of Yin and blood stasis; and the main positions for diabetic patients were liver, spleen and kidney. Patients with impaired fasting glucose were Qi deficiency; Patients with impaired 2-hour postprandial glucose were Qi deficiency or pathogenic wind attacking collaterals; Patients with abnormal hemoglobin were Qi deficiency and Yin deficiency.

关 键 词：糖尿病 2 型 糖尿病并发症 证候 数据挖掘 靶位 理化指标 因子分析 贝叶斯网络 

分 类 号：R587.1[医药卫生—内分泌]