头穴丛刺对老年性痴呆大鼠学习记忆能力的影响  

Effect of Cluster Needling at Scalp Point on Learning and Memory Function of Alzheimer's Rats

作　　者：李虹霖[1] 孙兴华[1] 李默[1] 徐飞[2] 张淼[1] 

机构地区：[1]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001 [2]黑龙江省医院,黑龙江哈尔滨150036

出　　处：《针灸临床杂志》2015年第10期74-76,共3页Journal of Clinical Acupuncture and Moxibustion

基　　金：黑龙江省教育厅科学技术研究项目;编号:12541753

摘　　要：目的:探讨头穴丛刺对老年性痴呆大鼠学习记忆能力的影响。方法:将48只Wistar大鼠随机分成模型组、假手术组、治疗组、对照组4组,采用Aβ1-42寡聚体双侧海马区注射制备老年性痴呆大鼠模型,造模成功后进行4周的针刺干预,治疗组采用头穴丛刺,对照组针刺双侧肾俞、足三里穴。4周后观察大鼠逃避潜伏期、第2象限时间百分比及穿越次数的变化。结果:从水迷宫实验第2天起,治疗组逃避潜伏期明显缩短,与对照组相比具有极显著性差异(P<0.01),治疗组下降趋势明显快于对照组;第2象限时间百分比中,治疗组与对照组相比具有显著性差异(P<0.05);穿越次数中,治疗组与对照组相比无显著性差异(P>0.05)。结论:头穴丛刺能够改善大鼠学习记忆能力及提高大鼠记忆保持能力。Objective： To explore the effect of cluster needling at scalp point on learning and memory function of Alzheimer ＇s rats. Methods： Forty eight Wistar rats were randomized into four groups including a model group,a sham operation group,an observation group and a control group. Establish models with Alzheimer＇s disease by injecting Aβ1- 42 oligomer into bilateral hippocampus. After the successful modeling,all rats were treated by acupuncture for four weeks. The observation group was intervened by cluster needling at scalp point,and the control group only received needling at bilateral BL23 and ST36. After the treatment for four weeks,observe the changes of escaping latency,percentage of the second quadrant time and traversing times. Results： From the second day of water maze test,it was significantly shorter of escaping latency in the observation group,with significant differences compared with the control group（ P〈0. 01）. It showed a markedly faster downward trend in the observation group compared with the control group. In the observation of percentage of the second quadrant time,it showed marked differences between the observation group and the control group（ P〈0. 05）. While,there was no statistical difference in traversing times between the observation group and the control group（ P〉0. 05）. Conclusion： The cluster needling at scalp point has a marked effect on ameliorating learning and memory function and improving memory- maintaining ability of Alzheimer＇s rats.

关 键 词：头穴丛刺 老年性痴呆 学习记忆 实验研究 

分 类 号：R246.6[医药卫生—针灸推拿学]