吉林人参低聚肽对雄性小鼠性功能影响的实验研究  

Effects of Panax ginseng oligopeptide of Jilin on sexual function in male mice

作　　者：鲍雷[1] 王军波[1] 张远[1] 蔡夏夏[1] 孙彬[1] 陈启贺 任金威[1] 张召锋[1] 李勇[1] 

机构地区：[1]北京大学医学部公共卫生学院营养与食品卫生学系,北京100191

出　　处：《中国预防医学杂志》2015年第10期757-760,共4页Chinese Preventive Medicine

基　　金：十一五国家科技支撑项目(2006BAD27B08)

摘　　要：目的探讨吉林人参低聚肽对雄性小鼠性功能的影响。方法健康清洁级成年ICR雄性小鼠168只,随机分为7组,分别为空白对照组、乳清蛋白组(0.50g/kg bw)及5个吉林人参低聚肽剂量组(0.125g/kg bw、0.25g/kg bw、0.50g/kg bw、1.00g/kg bw、2.00g/kg bw)。连续灌胃30d后,检测血清中NO和睾酮含量,分别取睾丸、精囊和前列腺并精确称重,进行交配实验记录交配潜伏期及20min内交配的次数。结果各项指标中空白对照组与乳清蛋白组之间差异均无统计学意义;与乳清蛋白组相比,吉林人参低聚肽各剂量组可不同程度的增加雄性小鼠附性器官指数,提高血清中的NO和睾酮浓度,缩短小鼠交配潜伏期并增加交配次数。结论吉林人参低聚肽可提高小鼠性功能。Objective To assess the effects of Panax ginseng oligopeptide of Jilin on sexual function in male mice. Methods 168 male ICR mice were randomly divided into 7groups and treated with whey protein（0.50g/kg bw）and 5different doses of Panax ginseng oligopeptide of Jilin（0.125g/kg bw,0.25g/kg bw,0.50g/kg bw,1.00g/kg bw,2.00g/kg bw）for 30 days.One group of mice served as controls.The serum levels of testosterone and NO in mice were measured.Testicles,seminal vesicles and prostate glands of male mice were all weighed.The sexal activity of male mice,such as incubation period of the first intercourse and the total number of intercourse in 20 min were recorded. Results There were no significant differences of all testing indicators between mice in control group and whey protein group.Compared with whey protein,Panax ginseng oligopeptide of Jilin could significantly increase the weight of accessory sex organs（P〈0.05）and serum levels of testosterone and NO（P〈0.01）,shorten the incubation period of the first intercourse（P〈0.05）and increase the total numbers of intercourse in 20min（P〈0.01）. Conclusions Panax ginseng oligopeptide of Jilin is able to improve the sexual function of male mice.

关 键 词：吉林人参低聚肽 性功能 睾酮 一氧化氮 

分 类 号：R285.5[医药卫生—中药学]