右旋酮洛芬氨丁三醇注射液中葡辛胺的HPLC-ELSD法测定  

Determination of N-Octyl-D-glucamine in Dexketoprofen Trometamol Injection by HPLC-ELSD

作　　者：凌飒[1] 梁璐[1] 戴正琳[1] 张周菊[1] 钟巧妮[1] 

机构地区：[1]湖北省医药工业研究院有限公司,湖北武汉430061

出　　处：《中国医药工业杂志》2015年第11期1227-1229,共3页Chinese Journal of Pharmaceuticals

摘　　要：建立了高效液相色谱-蒸发光散射检测法测定右旋酮洛芬氨丁三醇注射液中的葡辛胺。采用Agilent Zorbax C18柱,以水（冰乙酸调至p H 3.5）∶乙腈为流动相,梯度洗脱,以蒸发光散射检测器检测。葡辛胺在0.005~0.25 mg/ml范围内线性关系良好。平均回收率为98.4%,RSD为1.1%。An HPLC-ELSD method was established for the determination of N-octyl-D-glucamine in dexketoprofen trometamol injection. An Agilent Zorbax C18 column was used, with the mobile phase of water （adjusted to pH 3.5 by glacial acetic acid） ： acetonitrile by gradient elution. An evaporative light scattering detector was used. It was linear for N-octyl-D-glucamine in the range of 0.005 - 0.25 mg/ml. The average recovery was 98.4%, with RSD of 1.1%.

关 键 词：右旋酮洛芬氨丁三醇注射液 葡辛胺 高效液相色谱 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.72[化学工程—制药化工]