睡眠剥夺影响大脑情绪功能网络的静息态功能磁共振成像研究  

Effect of sleep deprivation on brain emotional function network: a resting-state fMRI study

作　　者：雷煜[1] 王路斌[1] 邵永聪[1] 叶恩茂[1] 杨征[1] 

机构地区：[1]军事医学科学院基础医学研究所军事心理学教研室,北京100850

出　　处：《第三军医大学学报》2015年第22期2278-2284,共7页Journal of Third Military Medical University

基　　金："十二五"国家科技支撑计划(2013BAHD2806);全军后勤科研"十二五"重大项目:(BWS11J045;AWS12J003)~~

摘　　要：目的探讨睡眠剥夺引起情绪紊乱的大脑功能网络机制。方法采用重复测量自身前后对照设计,利用静息态功能磁共振成像技术,比较睡眠剥夺前后大脑杏仁核3个亚区的全脑功能连接模式表征以及与情绪状态变化的关系。结果睡眠剥夺导致背外侧前额叶、背侧前扣带回、背侧后扣带回以及额下回和杏仁核3个亚区功能连接减弱(P<0.05);后扣带回/楔前叶、内侧前额叶、喙部前扣带回以及海马旁回功能连接上升。与睡眠剥夺前相比,剥夺后POMS总分显著升高,与内侧前额叶和杏仁核SFA区的功能连接强度显著正相关(r=0.415,P<0.05)。结论睡眠剥夺对杏仁核功能连接模式的影响存在明显的区域和网络特异性,杏仁核与默认网络脑区之间的功能连接上升,而与执行控制网络脑区之间的功能连接减弱,可能是睡眠剥夺后情绪调控能力下降的重要神经机制。Objective To investigate the brain neutral mechanism of emotional disturbance induced by sleep deprivation. Methods Resting-state functional magnetic resonance imaging（ fM RI） was used to compare the whole brain functional connectivity patterns of 14 male young healthy voluen teers in the rested wakefulness state and sleep deprivation state. Results Sleep deprivation resulted in a significant decrease in the functional connectivity between the sub regions of amygdala and several regions including the dorsolateral prefrontal cortex,dorsal anterior cingulate cortex,dorsal posterior cingulate cortex and inferior frontal gyrus（ P 0. 05）. The functional connectivity was significantly increased between the sub regions of amygdala and several regions including the posterior cingulate cortex / presumes,medial prefrontal cortex,rostral anterior cingulate cortex and parahippocampal gyrus. Furthermore,the total score of profile of mood states（ POMS）was significantly higher in the sleep deprivation state than in the rested wakefulness state. The functional connectivity between the superficial amygdala and medial prefrontal cortex was significantly correlated with the POMS total score（ r = 0. 415,P 0. 05）. Conclusion Different sub regions of amygdala have distinct functional connectivity patterns. After sleep deprivation,the functional connectivity between the amygdala and regions of default mode network is increased while that between the amygdala and regions of executive control network is decreased. These alterations may be the essential neural mechanism of emotion regulation decline induced by sleep deprivation.

关 键 词：睡眠剥夺 杏仁核 静息态 功能连接 

分 类 号：R338.63[医药卫生—人体生理学]