海南省恶性疟原虫对青蒿琥酯的敏感性监测  

Surveillance of sensitivity of Plasmodium falciparumin to artesunate in Hainan province

作　　者：冯晓平[1] 王善青[2] 林世干[2] 刘德全[1] 夏志贵[1] 

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所卫生部寄生虫病原与媒介生物学重点实验室世界卫生组织疟疾血吸虫病和丝虫病合作中心,上海200025 [2]海南省疾病预防控制中心,海南海口570203

出　　处：《中国热带医学》2015年第10期1241-1243,共3页China Tropical Medicine

基　　金：世界卫生组织热带病研究和培训特别规划署项目WHO/TDR(900098);世界卫生组织西太区办事处项目(ID MVP/CHN/02/01)

摘　　要：目的了解恶性疟原虫对青蒿琥酯的敏感性。方法研制成功青蒿琥酯涂药板和便于现场使用的培养基后,1986—2007年采用世界卫生组织(WHO)推荐的体外微量法,在海南省开展了恶性疟原虫对青蒿琥酯的敏感性监测。结果 1986—2007年共监测了8次,检测237例病人,完全抑制疟原虫裂殖体形成的平均药浓度,乐东县抱由镇由1986年0.028 pmol/μL血升至2002年0.135 pmol/μL血,升高至4.82倍(P<0.01);≥4pmol/μL血完全抑制裂殖体形成例数所占百分比,由1986年的5.5%升至2002年为21.8%,升高至3.96倍(P<0.01)。三亚市雅亮乡的检测结果与乐东县抱由镇2002年的结果基本相似。结论海南省恶性疟原虫对青蒿琥酯敏感性在逐渐下降。Objective To assess the sensitivity of Plasmodium falciparum to artesunate. Methods Since the successfulpreparation of the artesunate microplates and medium for field application, an in vitro microassay recommended by the WHOwas used to ascertain the sensitivity of Plasmodium falciparum to artesunate during 1986-2007 in Hainan province. Results A total of 237 falciparum malaria patients were enrolled into 8 trials.The mean concentration of artesunate for completeinhibition of schizont formation in Baoyou townsip of Ledong county was increased from 0.028pmol//μL blood in 1986 by 4.82 times to 0.135pmol/μL blood in 2002（P〈0.0）,and the proportion of cases having≥4pmol//μL blood for complete inhibitionof schizont formation was increased from 5.5% in 1986 by 3.96 times to 21.8% in 2002（P〈0.0）.The results in Yaliangtownship of Sanya city were similar to those in 2002 of Baoyou township. Conclusion The sensitivity of P. falciparum toartesunate was gradually decreasing in Hainan Province.

关 键 词：青蒿琥酯 敏感性 体外微量法 监测 恶性疟原虫 

分 类 号：R531.3[医药卫生—内科学]