辛伐他汀对动脉粥样硬化者血清瘦素和一氧化氮的影响  

The effects of simvastatin on serum leptin and nitric oxide in patients with atherosclerosis

作　　者：顾申红[1] 李莹[1] 宋艳玲[1] 麦华德 曾望远[1] 王雅纯[1] 

机构地区：[1]海南医学院附属医院老年科,海南海口570102

出　　处：《中国热带医学》2015年第10期1244-1245,1248,共3页China Tropical Medicine

基　　金：海南省卫生厅重点科研课题(No.琼卫2010重点-09)

摘　　要：目的探讨辛伐他汀对动脉粥样硬化(AS)患者血清瘦素、高敏C反应蛋白(hs-CRP)和一氧化氮(NO)水平的影响。方法选取颈动脉粥样硬化患者62例为观察组,选取该期间到海南医学院附属医院健康体检人员110名为对照组,同时检测血浆瘦素(LP)、血脂水平、hs-CRP、NO和内皮素-1(ET-1),给予AS患者服用辛伐他汀40 mg,1次/d,观察并分析服用前及服药后3个月和6个月后上述指标的变化。结果 AS组患者除TC、低密度脂蛋白(LDL-C)增高外,血清瘦素水平Lp、hs-CRP和ET-1水平均大于正常对照组,而NO水平低于对照组;AS患者在应用辛伐他汀40 mg,1次/d,治疗后与治疗前相比,血清瘦素、LDL-C、hs-CRP和ET-1水平显著下降(P<0.01),而血清NO浓度明显上升(P<0.05)。结论辛伐他汀在降低LDL-C的同时,还可降低血清瘦素、hs-CRP,升高NO浓度,多重机制干预AS的进展。尽早使用他汀类药物有助于延缓AS的发展,降低动脉硬化性心血管疾病的风险。Objective To study the effects of simvastatin on serum leptin,hypersensitive C-reactive protein（hs- CRP）,and nitric oxide（NO）levels in patients with atherosclerosis（AS）. Methods A total of 62 patients with carotid atherosclerosiswere selected as observation group,and 110 normal check-up personnel as control group during the same time. Serum leptin（LP）,cholesterol,hs-CRP,nitric oxide（NO）and endothelin 1（ET- 1）levels were detected,then the observation group weregiven simvastatin 40 mg qn,and tested the indicators again after 3 months and 6 months in both groups. Results The patientsin observation group were with higher levels of total cholesterol（TC）,low-density lipoprotein（LDL-C）,the serum leptin（Lp）,hs-CRP,ET-1,and lower levels of NO,compared to control group; After the medication of simvastatin 40 mg qn,LDL-C,hs-CRP and ET- 1 levels in observation group decreased significantly（P〈0.0）,while NO significantly increased（P〈0.05）.Conclusion Simvastatin can reduce serum LP and hs-CRP,and increase NO level while reducing LDL-C. The mechanismmay be multiple interventions of atherosclerosis progress. The use of statins may help to slow down the progress of theatherosclerosis as soon as possible,and reduce atherosclerotic risk of cardiovascular disease.

关 键 词：辛伐他汀 动脉粥样硬化 瘦素 超敏C反应蛋白 一氧化氮 

分 类 号：R543.12[医药卫生—心血管疾病]