CD40基因多态性与Graves病相关性的Meta分析  

The association between the polymorphisms in the CD40 gene and Graves′disease:a Meta analysis

作　　者：胡卓清 陈晓铭[1] 李潍[1] 武革[1] 

机构地区：[1]广东医学院附属医院内分泌科,广东湛江524001

出　　处：《重庆医学》2015年第32期4544-4548,4552,共6页Chongqing medicine

基　　金：广东省社会发展领域科技计划项目(2012B031800489);广东省医学科研基金立项课题(A2013432);湛江市非资助科技攻关计划项目(2013B01030)

摘　　要：目的 Meta分析确定CD40-1C/T多态性（rs1883832）与Graves病的关系。方法检索PubMed、中国生物医学文献数据库（CBM）、维普、万方、中国学术期刊网络出版总库（CNKI）及Cochrane library数据库获取相关文献,用RevMan5.2及STATA12.0合并分析。结果纳入标准文献18篇（病例组5 198例,对照组4 417例）,合并结果表明等位基因C/T及基因型的分布频率在两组差异有统计学意义（P〈0.05）,CC和（或）CT基因的个体有增加Graves病发病的风险（CC vs.TT：OR=1.60,95%CI=1.28-2.00,P〈0.01;CC vs.CT：OR=1.25,95%CI=1.14-1.37,P〈0.01;CC vs.CT＋TT：OR=1.34,95%CI=1.17-1.52,P〈0.01;CC＋CTvs.TT：OR=1.36,95%CI=1.13-1.64,P〈0.01）。亚组分析表明对照组甲状腺抗体Ab（±）/Ab（-）是异质性的主要来源,敏感性分析结果比较稳健,无明显发表偏倚。等位基因及基因型分布频率在伴Graves病眼病/不伴Graves病眼病、有Graves病家族史/无Graves病家族史这两个亚组中均差异无统计学意义（均P〉0.05）。结论 CD40基因多态性（rs1883832）与Graves病发病相关,但与Graves病眼病及家族史无关系。Objective To investigate the associations between the polymorphisms in CD40-1C/T polymorphism（rs1883832）and Graves′disease by Meta-analysis.Methods We searched Pubmed,CBM,VIP,CNKI,Cochrane library and Wanfang,covering and selecting literatures according to criterions.Statistical analysis was performed by using Revman5.2and Stata12.0.Results A total of 18 eligible literatures were included（5 198 cases and 4 417controls）,The pooling results suggested that significant difference in allele C/T frequency and genotype frequency were observed between patients with and control subjects（P〈0.05）;the individuals of genotype CC and（or）CT have significantly increased Graves′disease risk（CCvs.TT：OR=1.60,95%CI=1.28-2.00,P〈0.01;CC vs.CT：OR=1.25,95%CI=1.14-1.37,P〈0.01;CC vs.CT＋TT：OR=1.34,95%CI=1.17-1.52,P〈0.01;CC＋CTvs.TT：OR=1.36,95%CI=1.13-1.64,P〈0.01）.From subgroup analysis,we identified that the research subjects difference showed between thyroid anti-body（Ab±）and thyroid anti-body（Ab-）in control group,which might be the cause of heterogeneity,but the pooling results in sensitivity analysis were stable and no significant publication bias were found.No significant difference in allele and genotype frequency of CD40 SNP were observed between Graves′disease with ophthalmopathy group and Graves′disease without ophthalmopathy group,Graves′disease with family history group and Graves′disease without family history group（all P〈0.05）.Conclusion This Meta analysis indicated that the polymorphisms in the CD40gene（rs1883832）was related with Graves′disease,but had nothing to do with family history and Graves′disease with ophthalmopathy.

关 键 词：格雷夫斯病 抗原 CD40 基因型 多态现象 遗传 META分析 

分 类 号：R581.1[医药卫生—内分泌]