盐酸氢吗啡酮注射液治疗慢性疼痛的有效性：meta分析  

Efficacyof hydromorphone hydrochloride injection for treatment of chronic pain ： a meta-analysis

作　　者：曾铮[1] 武庆平[2] 姚尚龙[2] 尹平[3] 付阿丹[4] 

机构地区：[1]华中科技大学同济医学院附属武汉中心医院医学资讯科,430014 [2]华中科技大学同济医学院附属协和医学院麻醉科 [3]华中科技大学同济医学院公共卫生学院流行病学与卫生统计学系 [4]华中科技大学同济医学院附属武汉中心医院护理部

出　　处：《中华麻醉学杂志》2015年第8期966-968,共3页Chinese Journal of Anesthesiology

摘　　要：目的 采用meta分析评价盐酸氢吗啡酮注射液治疗慢性疼痛的有效性.方法 检索Web of Science Proceedings和PubMed数据库,无语种和发表时间限制.收集评价盐酸氢吗啡酮注射液治疗慢性疼痛有效性的临床研究.主要评价指标包括：VAS评分、疼痛控制率或缓解率等.由2名研究人员独立地筛选研究并提取数据,并利用Stata 10软件进行数据分析.结果 最终共11项研究符合纳入标准,共452例患者.与治疗前比较,盐酸氢吗啡酮注射液治疗后VAS评分降低（P＜0.05）.对于癌性疼痛患者,与其他阿片类镇痛药比较,盐酸氢吗啡酮注射液治疗后VAS评分降低,疼痛缓解率或控制率升高（P＜0.05）.结论 盐酸氢吗啡酮注射液可治疗慢性疼痛,其对癌性疼痛患者的治疗效果可能优于其他阿片类镇痛药物.Objective To systematically review the efficacy of hydromorphone hydrochloride injection for treatment of chronic pain.Methods Web of Science Proceedings and PubMed were searched for clinical trials involving the efficacy of hydromorphone for treatment of chronic pain, with no language or time limit.Evaluation indexes included visual analogue scale （VAS） score and the rate of pain control or relief.The studies were screened independently, and the data were extracted by two researchers.Meta-analysis was conducted using the Stata 10 software.Results Eleven studies involving 452 patients were included in our meta-analysis.VAS score was significantly decreased after treatment compared with that before treatment.For the patients with cancer pain, VAS score was significantly decreased after treatment with hydromorphone hydrochoride injection, and the rate of pain control or relief was increased when compared with the other opioid analgesics.Conclusion Hydromorphone hydrochloride injection can treat chronic pain, and it may provide better therapeutic effect than the other opioid analgesics for the patients with cancer pain.

关 键 词：氢吗啡酮 注射剂 疼痛 慢性病 

分 类 号：R402[医药卫生—临床医学]