促胰液素对小脑浦肯野细胞抑制性突触的调节  

Regulation of secretin on inhibitory synapses of cerebellar Purkinje cells

作　　者：张颖[1] 杨永滨[2] 

机构地区：[1]哈尔滨医科大学生理教研室 [2]哈尔滨医科大学机能实验中心,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2015年第5期393-396,共4页Journal of Harbin Medical University

基　　金：黑龙江省教育厅科学技术研究项目资助(12521215)

摘　　要：目的观察促胰液素(secretin)对小脑中间神经元—浦肯野细胞抑制性突触的影响。方法采用小脑脑片膜片钳技术,脑片灌流液中给予secretin,观察其对浦肯野细胞上抑制性突触后电流的影响。结果 Secretin应用后,浦肯野细胞诱发性抑制性突触后电流增强;自发性抑制性突触后电流也增强。结论 Secretin可能参与调节浦肯野细胞的功能及其信号传递,从而参与小脑功能的调节。Objective To investigate the effect of secretin on the GABA-ergic synapse in the cerebellum and its mechanism. Methods Evoked inhibitory postsynaptic current（ e IPSC） induced by stimulating the presynaptic neurons and spontaneous inhibitory postsynaptic current（ s IPSC） of Purkinje cells in the cerebellum were recorded. Results After the treatment of secretin,not only the amplitude of e IPSC recording on purkinje cells was increased,but also s IPSC. Conclusion Secretin facilitates the inhibitory synaptic transmission on the Purkinje cells in the rat cerebellum,and it may be involved in the modulation of the cerebellum＇s function.

关 键 词：促胰液素 抑制性突触 GABA 浦肯野细胞 

分 类 号：R338.2[医药卫生—人体生理学]