苏州地区人副流感病毒3感染住院患儿临床特征  

Clinical features of human parainfluenza virus type 3( HPIV3) infection in Suzhou area

作　　者：赵显虹[1] 王宇清[1] 

机构地区：[1]苏州大学附属儿童医院呼吸科,江苏苏州215003

出　　处：《临床肺科杂志》2015年第12期2214-2216,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的：探讨苏州地区因急性呼吸道感染住院患儿中副流感病毒3型（ HPIV3）感染临床特征。方法收集2013年1月-2013年12月因急性呼吸道感染住院2298例患儿的痰标本,应用直接免疫荧光法测呼吸道合胞病毒、流感病毒（A、B）、人副流感病毒（1-3）和腺病毒,采用实时PCR检测人博卡病毒DNA,逆转录PCR检测人偏肺病毒及鼻病毒RNA。分析人副流感病毒3型感染患儿的临床特点及流行病学特征,并与呼吸道合胞病毒（RSV）感染进行比较。结果2298例痰标本中病毒检测阳性者983例（42.78%）,HPIV 3阳性98例（4.26%）,次于RSV阳性233例（10.14%）；HPIV3常年均可感染,以春、夏季为发病高峰,夏季发病率高达45.92%；发病年龄均为6岁以下儿童,1岁以下检出率高,占62.30%；98例阳性标本中,HPIV3单独感染61例,主要引起支气管肺炎（80.33%）、急性毛细支气管炎（13.11%）,以咳嗽（96.72%）、喘息（44.26%）、发热（47.54%）为主要临床症状；与RSV比较,HPIV3住院患儿喘息发生率低,主要引起支气管肺炎,差异有统计学意义（P〈0.05）。结论 HPIV3是苏州地区住院患儿呼吸道感染的重要病原之一,其有单独的致病性,与RSV相比,在季节分布、临床表现等方面有一定差异。Objective To investigate the clinical features of human parainfluenza virus type 3 （ HPIV3 ） infection in Suzhou area. Methods From January 2013 to December 2013, the respiratory sputum was collected from 2298 patients with acute infections. Direct immunofluorescence was applied to test parainfluenza virus （1-3）, influenza virus A and B, respiratory syncytial virus （ RSV） and adenovirus. DNA of HBoV was tested by real-time PCR, and RNA of human metapneumovirus and human rhinovirus was tested by reverse-transcription. The epidemiology and clinical features of patients with HPIV3 infection were analyzed and compared with those RSV infection. Results The positive rate of virus was 42. 78% （983 cases）, the positive rate of HPIV3 was 4. 26% （98 cases）, and 10. 14% of postive ferior RSV （233 cases）. HPIV3 infection could occur all the year around but most seen in spring and summer, with the highest incidence of 45. 92% in summer. The highest detection rate （60. 20%） occurred in patients aged from 1 to 12 months, almost younger than 6 years old. 61 cases were the only pathogen of HPIV3. Cough （96. 72%）, wheezing （44. 26%） and fever （47. 54%） were more common in patients with HPIV3. The percentage of bronchopneumonia caused by HPIV3 infection was 80. 33%. Compared with RSV infection, HPIV3 had a less incidence of wheezing （P＆lt;0. 05）. Conclusion HPIV3 is one of the most importment viral pathogens in children with respiratory infection in Suzhou area. Infection can be caused by HPIV3 only. The occurrences of season and clinical feature of HPIV3 infection are difference with RSV infection.

关 键 词：人副流感病毒3型 呼吸道合胞病毒 临床特征 儿童 

分 类 号：R725.6[医药卫生—儿科]