中医五行音乐对慢性温和刺激所致抑郁小鼠的抗抑郁作用研究  

Antidepressant Effect of Traditional Chinese Medicine Five Element Music on Chronic Mild Stress Model of Depression in Mice

作　　者：程虹毓[1] 熊浩仲[1] 朱继孝[1] 李雪溦 

机构地区：[1]江西中医药大学,江西南昌330004

出　　处：《中医药导报》2015年第21期9-12,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：江西省卫生厅中医药科研计划项目(2013B004)

摘　　要：目的:研究中医五行音乐对慢性温和刺激所致抑郁小鼠的抗抑郁作用及作用机制。方法:采用慢性刺激复制抑郁症小鼠模型,通过体质量、悬尾实验、强迫游泳实验和开场实验对小鼠进行行为学评价,并测定小鼠血清5-HT(五羟色胺)、海马组织中MAO(单胺氧化酶)及肝组织中MDA(丙二醛)含量。结果:与模型组比较,音乐治疗组抑郁症小鼠体质量显著增加(P<0.01),悬尾和强迫游泳实验不动时间均显著缩短(P<0.01),开场实验爬行格子数和站立次数均显著增加(P<0.05);音乐治疗能显著提高抑郁症小鼠血清5-HT的水平(P<0.01),降低海马组织中MAO含量(P<0.05),降低肝脏组织中MDA含量(P<0.05)。五行音乐治疗与氟西汀联合治疗效果优于音乐治疗和氟西汀单用。结论:音乐治疗对抑郁症有一定治疗效果,可能通过多种途径发挥治疗抑郁的作用。Objective： To explore the antidepressant-like effect of traditional Chinese medicine five element music on chronic mild stress model of depression in mice. Methods： The depression model of the mice was induced by chronic unpre- dictable mild stress. The behaviors were evaluated by body weight, tail susoension, forced swimming and open-field tests. The changes of 5-HT in serum, MAO in hippocampus and MDA in liver was determined. Results： Compared with the model group, music therapy significantly increased the weight of the depression model mice（P〈0.01）, significantly shortened the immobility time in tail suspension test and forced swimming test of depression model mice（P〈0.01）, significantly increased the numbers of squares crossed and stand-up times of depression model mice in open field test（P〈0.05）. Music therapy can reduce content of 5-HT in sereum （P〈0.01）, and incerase the content of MAO in hippocampus and MDA in liver （P〈0.05）. Conclusion： Music therapy showed a certain therapeutic effect on depression in different ways.

关 键 词：中医五行音乐 抑郁症 5-羟色胺 单胺氧化酶 丙二醛 小鼠 

分 类 号：R285.5[医药卫生—中药学]