脑损伤后锥体束Wallerian变性的氢质子磁共振波谱成像  

Proton Magnetic Resonance Spectroscopy of Wallerian Degeneration in Pyramidal Tract after Cerebral Injury

作　　者：严肃[1] 杨建忠[1] 吴立伟[1] 单海荣[1] 

机构地区：[1]宜兴市人民医院放射科

出　　处：《中国医学计算机成像杂志》2015年第5期501-504,共4页Chinese Computed Medical Imaging

基　　金：江苏大学2012年度医学临床科技发展基金(编号:JLY20120066)~~

摘　　要：目的:探讨氢质子磁共振波谱(1HMRS)成像技术检测和定量分析脑损伤后锥体束Wallerian变性的可行性。方法:对15例单侧脑损伤且出现同侧锥体束Wallerian变性患者和15例年龄匹配的健康志愿者(对照组)行常规MRI检查,并同时行1HMRS检查,测量双侧大脑脚锥体束走行区的NAA/Cr、Cho/Cr值,比较该值在脑损伤组与对照组间的差异。结果:脑损伤后同侧大脑脚谱线图显示NAA峰减低,Cho峰升高,NAA/Cr值较对侧明显减低,Cho/Cr值明显升高,与对侧及对照组比较,差异均存在统计学意义(P<0.001),而病变组对侧大脑脚及对照组双侧大脑脚的NAA/Cr、Cho/Cr值差异无统计学意义。结论:1HMRS技术可以检测并定量分析脑损伤后锥体束Wallerian变性。Purpose： To investigate the feasibility of proton magnetic resonance spectroscopy（1HMRS） for detection and quantitative analysis of Wallerian degeneration of the pyramidal tract after cerebral injury.Methods：Conventional MRI and 1HMRS were performed in 15 patients with Wallerian degeneration of the ipsilateral pyramidal tract after unilateral cerebral injury and 15 age-matched normal volunteers（the control group）. The ratios of NAA/Cr and Cho/Cr in bilateral cerebral peduncles were quantified using 1HMRS. The differences of the ratios between cerebral injury group and the control group were analyzed. Results： The result of the 1HMRS of ipsilateral cerebral peduncle in patients with cerebral injury showed that the NAA peak was reduced and the Cho peak was increased. The ipsilateral NAA/Cr values was significantly lower than that of the contralateral, the Cho/Cr values were increased obviously, there were significant differences between the two groups（P〈0.001）. The NAA/Cr and Cho/Cr values were with statistical significant differences between that of the ipsilateral and contralateral peduncle, and between that in the patient and control group（P〉0.05）. Conclusion： 1HMRS can be used to detect and quantitative analyze Wallerian degeneration of the pyramidal tract after cerebral injury.

关 键 词：氢质子磁共振波谱 WALLERIAN变性 锥体束 脑损伤 

分 类 号：R445.2[医药卫生—影像医学与核医学]