近红外光谱法快速检测肾上腺色腙片品质的应用研究  

Study on application of rapid detection for quality of Carbazochrome Tablets by near infrared spectroscopy

作　　者：李明梅[1] 裘兰兰[1] 王梅娟 

机构地区：[1]盐城卫生职业技术学院,江苏盐城224005 [2]江苏省盐城市药品检验所,224002

出　　处：《检验医学与临床》2015年第21期3167-3168,3171,共3页Laboratory Medicine and Clinic

基　　金：江苏省盐城市医学科技发展计划项目(YK2014059)

摘　　要：目的建立肾上腺色腙片近红外光谱技术的品牌判别模型,以打击假冒伪劣品。方法在Opus Setup Conformity Test模块中,建模参数：波段：9000-7500、6900-5600、5000-4250/cm,一致性指数（CI）值为7,平滑点为13,预处理方法为二阶导数＋矢量归一。通过以上参数,数据前处理后建立近红外一致性模型。结果江苏亚邦爱普森药业有限公司的调入12张验证肾上腺色腙片光谱均在CI值为7的限度范围内,而2批假冒的药品光谱均不在模型设定的CI值范围内。结论该方法建立的品牌模型,能快速鉴别该品牌药品的真伪,并可应用于日常监督中的药品初筛,以提高抽样命中率。Objective To establish the brand discrimination model of near infrared technology for Carbazochrome Tablets in order to attack the counterfeit products.Methods In the module of Opus Setup Conformity Test,the model-building parameters：the waveband was at the 9 000-7 500,6 900-5 600 and 5 000-4 250/cm,the CI value was 7,the smooth point was 13,the pre-processing method was second derivative plus vector normalization.The near infrared consistency model was established after the data pretreatment through the above parameters.Results12 pieces of spectrum for verifying Carbazochrome Tablets from Jiangsu Yabang Apusen Pharmaceutical Co.,Ltd.were all within the limitation range of CI value 7,while the spectrum of 2batches of counterfeit product exceeded the CI limit.Conclusion The brand model established by this method can rapidly identify the authenticity of this brand of drug,and can be used for the preliminary screening of drugs in the daily surveillance work in order to increase the sampling hit rate.

关 键 词：近红外光谱法 定性模型 肾上腺色腙片 

分 类 号：R284.1[医药卫生—中药学]