甘精胰岛素联合瑞格列奈治疗糖尿病的临床观察  

Clinical observation on effects of insulin glargine combined with repaglinide in treatment of diabetes

作　　者：王少蓉[1] 刘文莉[1] 帖丽丽[1] 

机构地区：[1]陕西省第二人民医院内分泌科,西安710005

出　　处：《检验医学与临床》2015年第21期3199-3201,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨甘精胰岛素联合瑞格列奈治疗糖尿病的临床应用效果。方法选择2011年8月至2014年5月收治的96例口服降糖药物治疗效果不佳的2型糖尿病患者作为研究对象,按随机数字表分为试验组和对照组。对照组患者采用诺和灵30R治疗,试验组患者采用甘精胰岛素联合瑞格列奈治疗,比较两组患者血糖、体质量指数(BMI)、糖化血红蛋白(HbA1c)、胰岛素用量、低血糖发生情况和血糖达标时间。结果两组患者治疗后血糖均明显下降,与治疗前比较差异均有统计学意义(P<0.05)。治疗后试验组患者血糖在早餐后2h、午餐后2h和晚餐后2h均低于对照组患者,差异均有统计学意义(P<0.05)。试验组患者BMI、胰岛素用量和血糖达标时间均低于对照组患者,而HbA1c下降水平高于对照组患者,差异均有统计学意义(P<0.05)。试验组患者低血糖总发生和夜间低血糖发生率均低于对照组患者,差异有统计学意义(χ2=9.140、7.500,均P<0.05)。结论甘精胰岛素联合瑞格列奈治疗糖尿病具有减少胰岛素用量及注射次数、血糖控制效果佳、安全性好的特点,是一种值得推荐的治疗方案。Objective To investigate the clinical effects of insulin glargine combined with repaglinide in the treatment of diabetes.Methods 96 cases of type 2diabetes mellitus（T2DM）with poor effect by oral hypoglycemic drugs in our hospital from August 2011 to May 2014 were chosen as the research subjects and divided into the experimental group and the control group according to the random number table method.The control group was treated with novolin 30 Rand the experimental group adopted the therapy of insulin glargine combined with repaglinide.The blood glucose,BMI,HbA1 c,dosage of insulin,hypoglycemia occurrence situation and time of blood glucose reaching target were compared between the two groups.Results The blood glucose after treatment in the two group were obviously decreased compared with before treatment,the difference was statistically significant（P〈0.05）.The blood glucose levels at 2hafter breakfast,2hafter lunch and at 2hafter supper in the experimental group were lower than those in the control group,the differences were statistically significant（P〈0.05）.BMI,HbA1 c,dosage of insulin and time of blood glucose reaching target in the experimental group were lower than those in the control group,while the HbA1 clevel was higher than that in the control group,the differences had statistical significance（P〈0.05）.The total incidence rate of hypoglycemia and incidence rate of hypoglycemia at night in the experimental group were lower than those in the control group,the differences were statistically significant（χ^2=9.140,χ^2=7.500,P〈0.05）.Conclusion Insulin glargine combined with repaglinide has the characteristics of less insulin dosage,better blood glucose control and good safety in treating T2 DM,which is a treatment scheme worthy to be recommended.

关 键 词：糖尿病 瑞格列奈 甘精胰岛素 诺和灵30R 

分 类 号：R587.1[医药卫生—内分泌]