慢性心力衰竭患者血清氨基末端脑钠肽前体及肌钙蛋白T的检测意义  

Significance of detection of serum NT-proBNP and cTnT in patients with chronic heart failure

作　　者：何蓉[1] 李俊峰[1] 薛成[1] 

机构地区：[1]四川省崇州市人民医院,611230

出　　处：《检验医学与临床》2015年第21期3204-3206,共3页Laboratory Medicine and Clinic

摘　　要：目的观察和分析慢性心力衰竭（CHF）患者血清氨基末端脑钠肽前体（NT-proBNP）及肌钙蛋白T（cTnT）水平的变化及其意义。方法选取100例CHF患者作为病例组,选取100例健康人作为健康对照组,对两组研究对象血清NT-proBNP水平和cTnT水平进行检测和比较。结果病例组患者的血清NT-proBNP和cTnT水平均明显高于健康对照组（t=22.154、4.817,P〈0.05）;随着患者心功能级别的升高,血清NT-proBNP和cTnT水平也呈现逐渐上升的趋势,不同心功能患者之间比较的差异均有统计学意义（q=3.463-26.384,P〈0.05）,上述两个指标均与患者的心功能级别呈正相关关系（rs=0.756、0.433,P〈0.05）。结论 CHF患者血清NT-proBNP和cTnT水平的明显升高反映了患者的心肌细胞损伤和心功能损害,与其心功能级别具有相关性,可作为评价患者心功能状态和病情严重程度的辅助指标。Objective To observe and analyze the changes and significance of serum N-terminal pro-brain natiuretic peptide（NT-proBNP）and cardiac troponin T（cTnT）in the patients with chronic heart failure（CHF）.Methods 100 cases of CHF were selected as the case group and 100 healthy persons were selected as the healthy control group.The serum NT-proBNP and cTnT levels in the two group were detected and compared.Results The serum NT-proBNP and cTnT levels in the case group were significantly higher than those in the healthy control group（t=22.154,4.817,P〈0.05）;with the increase of the cardiac function grade,the serum NT-proBNP and cTnT levels showed a gradually upward trend and the differences of the indexes among the different cardiac function grades were statistically significant（q=3.463-26.384,P〈0.05）;the above two indexes were positively correlated with the cardiac function grade（rs=0.756,0.433,P〈0.05）.Conclusion The significant increase of serum NT-proBNP and cTnT levels in the patients with CHF reflect the injury of myocardial cells and the damage of cardiac function,which are correlated with the cardiac function grade and can be used as the auxiliary indexes for evaluating the heart function status of the patients and the severity of the diseases.

关 键 词：慢性心力衰竭 氨基末端脑钠肽前体 心肌肌钙蛋白T 心功能分级 

分 类 号：R541.61[医药卫生—心血管疾病]