医用臭氧自体血回输对慢性乙型肝炎患者HBeAg、HBsAg及FibroScan的影响  

Effect of medical ozone autologous blood transfusion on Fibro Scan,HBsAg and HBeAg in patients with chronic hepatitis B

作　　者：康海燕[1] 董江龙[2] 李健[1] 陈蕾[1] 叶立红[1] 王艳[1] 王晓静[1] 王晨雪[1] 

机构地区：[1]河北省石家庄市第五医院,河北石家庄050021 [2]河北医科大学第三医院,河北石家庄050051

出　　处：《现代中西医结合杂志》2015年第33期3675-3677,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察医用臭氧对慢性乙型肝炎患者HBe Ag、HBs Ag及瞬时肝弹性测定(Fibro Scan)的影响,评估医用臭氧在慢性乙型肝炎患者中的抗病毒、抗纤维化作用。方法将120例HBe Ag阳性的慢性乙肝患者随机分成2组,治疗组给予医用臭氧自体血回输治疗(采集患者静脉抗凝全血100 m L,在其中缓慢注入100 m L 30μg/m L医用臭氧,然后再回输到静脉),每周3次;对照组给予聚乙二醇干扰素α-2a 180μg皮下注射,每周1次。观察2组治疗4周、8周、12周时血清HBs Ag、HBe Ag定量及Fibro Scan的变化。结果 2组在治疗4周、8周、12周时血清HBs Ag、HBe Ag定量及Fibro Scan均逐渐下降(P均<0.05);2组间各指标比较差异无统计学意义(P均>0.05);患者血清HBs Ag定量、HBe Ag定量与Fibro Scan之间呈正相关(r=0.764,0.779,P均<0.05)。结论医用臭氧自体血回输治疗慢性乙型肝炎与聚乙二醇干扰素α-2a效果相当,其抗病毒、抗纤维化效果确切。Objective It is to observe the influence of medical ozone on HBeAg, HBsAg and transient liver elasticity （Fi- broScan） in patients with chronic hepatitis B, and evaluate the antiviral and anti fibrosis effects of medical ozone in the treat- ment of chronic hepatitis B patients. Methods 120 patients with HBeAg positive chronic hepatitis B were randomly divided in- to two groups. The patients in the treatment group was treated with medical ozone autologous blood transfusion （anticoagulant venous blood 100 mL was collected from patients, which was slowly injected into the 100 mL 30 μg/mL of medical ozone, and then returned to the vein） , three times a week; the patients in the control group were treated with the polyethylene glycol inter- feron α-2a 180 μg by subcutaneous injection, once a week. The changes of serum HBeAg, HBsAg quantification and Fi- broScan value in the treatment of 4 weeks, 8 weeks, and 12 weeks were observed. Results The serum HBsAg, HBeAg quanti- fication and FibroScan value in the treatment of 4 weeks, 8 weeks, 12 weeks were gradually decreased in the two groups （all P 〈 0.05 ） ; and there was no significant difference between the two groups （ P 〉 0.05 ）. There was positive correlation between serum HBsAg, HBeAg quantification with FibroScan value （ r = 0. 764, 0. 779, all P 〈 O. 05 ）. Conclusion The effcet of med- ical ozone autologous blood transfusionin in the treatment of chronic hepatitis B is similar to polyethylene glycol interferon α - 2a, and it has the definite effect of anti viral and anti fibrosis.

关 键 词：乙型肝炎 医用臭氧 聚乙二醇干扰素Α-2A HBEAG定量 HBSAG定量 FIBROSCAN 

分 类 号：R512.62[医药卫生—内科学]