基于亚频段低频振幅分析2型糖尿病患者静息态脑功能的MRI研究  

Subbands analysis of amplitude of low-frequency fluctuations in type 2 diabetes mellitus patients： a resting-state functional MRI study

作　　者：刘代洪 段姗姗[2] 张久权[1] 张艳伟[1] 魏平[2] 王健[1] 

机构地区：[1]第三军医大学第一附属医院放射科,重庆400038 [2]第三军医大学第一附属医院内分泌科,重庆400038

出　　处：《中华放射学杂志》2015年第11期801-806,共6页Chinese Journal of Radiology

基　　金：国家自然科学基金（81471647）

摘　　要：目的采用亚频低频振幅分析方法，研究2型糖尿病（T2DM）患者大脑静息态自发性活动改变特点，探讨其与T2DM患者认知功能损害间可能存在的关系。方法2013年12月至2014年6月招募22名T2DM患者（T2DM组）及23名正常志愿者（HC组），采集2组受试者人口学数据和空腹血糖（FPG）、糖化血红蛋白（HbA1c）等数据，利用简易精神状态检查量表（MMsE）评估2组受试者的总体认知水平，利用听觉词语学习测试（AVLT）评估T2DM组记忆力，评估指标包括即刻记忆、短时延迟记忆、长时延迟记忆、长时再认及AVLT总分。所有受试者均进行MRI扫描，采集3D-T1结构数据及静息态功能数据，采用静息态数据处理助手软件（DPARSFV2．3）计算Slow-5（0．010-0．027Hz）和Slow-4（0．027～0．073Hz）2个亚频段的分数低频振幅（fALFF）值，然后采用RESTV1．8软件进行组内和组间fALFF参数图的t检验，提取T2DM患者差异脑区的fALFF值，以年龄为控制变量，与FPG、HbA1c及量表评分行偏相关分析。结果与HC组比较，T2DM组在Slow-5亚频段fALFF值增高的脑区包括双侧扣带回前部、左侧小脑8区（体素数目分别为130、89，t值分别为4．4487、3．8409，P值均〈0．05），减低的脑区包括双侧枕中回和楔前叶（左、右侧体素数目分别为102、151，t值分别为-3．4806、-5．1355，P值均〈0．05）。T2DM组在Slow-4亚频段fALFF值增高的脑区有左侧颞下回（体素数目为104，t=4．8631，P〈0．05），减低的区域有右侧舌回（体素数目为91，t=-3．7146，P〈0．05）。右侧枕中回和楔前叶fALFF值与AvLT即刻记忆评分呈正相关（r=0．456，P=0．038）。结论T2DM患者存在多个与认知功能相关的脑区自发性活动异常，包括Slow-5亚频段的默认网络部分脑区和Slow-4亚频段的语义认知、视觉信息处理相关脑区，并且T2DM患者异常活动脑区在不同亚频段具有不同的�Objective To investigate changes of spontaneous brain activity in patients with type 2 diabetes mellitus （T2DM） by fractional amplitude of low-frequency fluctuations （fALFF） on subbands, and the possible relationship between these changes and cognitive impairment caused by T2DM. Methods Twenty-two T2DM patients and twenty-three healthy control subjects were involved in this study between December 2013 and June 2014 and the demographic and clinical data （fasting plasma glucose and HbA1c level） were obtained in all subjects. General cognition was assessed by MMSE in all subjects, and memory performance was assessed by Auditory Verbal Learning Test （AVLT） in T2DM group. 3D-T1 structural and resting-state functional MRI data were collected by MR scanner. Then fALFF value on slow-5 （0.010-0.027 Hz） and slow-4 （0.027-0.073 Hz） were calculated respectively using DPARSF V2.3. Intra-group and inter-group t-tests were conducted by REST V1.8. Partial correlation among fALFF values extracted from significantly different brain regions, clinical data and AVLT score of T2DM patients were calculated , using age ascovariate. Results Compared to the healthy controls, T2DM patients showed increased fALFF values in bilateral anterior cingulate gyms （cluster=130, t=4.4487, P〈0.05） and partial left cerebelum areas （cluster= 89, t=3.8409, P〈0.05） in frequency band slow-5. Moreover, the T2DM patients showed decreased fALFF values in bilateral middle occipital gyms and precuneus （Left： cluster=102, t=-3.4806. Right： cluster=151, t=-5.1355. All P〈0.05） in frequency band slow-5. While in frequency band slow-4, the T2DM patients showed increased fALFF values in left inferior temporal gyms （cluster=104, t=4.8631, P〈0.05）, and decreased fALFF values in right lingual gyrus （cluster=91, t=-3.7146, P〈0.05）. There was positive correlation between fALFF values of middle occipital gyms and precuneus and AVLT immediate memory score （r=0.456, P=0.038）. Conclusions T2DM patients exhibit ab

关 键 词：糖尿病 2型 磁共振成像 认知科学 

分 类 号：R587.1[医药卫生—内分泌]