白细胞介素6基因单核苷酸多态性与新疆维吾尔族人群自然长寿之间的关系  

Association of single nucleotide polymorphisms of IL-6 gene with longevity in Uyghurs in Xinjiang

作　　者：古丽孜巴尔·马木提 胡瑶[2] 陈凤辉[3] 黎怀星[2] 程祖亨[3] 玛依拉·吾甫尔[1] 

机构地区：[1]新疆医科大学第一附属医院综合心内科,乌鲁木齐830054 [2]上海中国科学院营养研究所 [3]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054

出　　处：《中华医学杂志》2015年第42期3428-3431,共4页National Medical Journal of China

基　　金：国家自然科学基金（31160215）

摘　　要：目的 初步探讨促炎症细胞因子基因变异是否与新疆维吾尔族人群自然长寿有关联.方法 将在1999至2012年纳入的240名来自新疆维吾尔自治区和田地区的维吾尔族长寿老人（≥90岁）和百岁老人作为长寿组,以及此期间同一地区与长寿组无任何血缘关系的92名在59～ 73岁之间自然死亡的维吾尔族人群作为对照组,检测肿瘤坏死因子α（TNF-α） （rs1800629）、白细胞介素6（IL-6）（rs1800796、rs10499563）、C反应蛋白（CRP）（rs2808630、rs1205）和IL-1β（rs1143623、rs16944）4个基因中7个单核苷酸多态性（SNP）位点.用logistic回归法评估病例-对照研究分析得出的各SNP与维吾尔族人群自然长寿之间的关联.结果 长寿组IL-6基因rs1800796位点C等位基因频率（0.298）低于对照组（0.435）,差异有统计学意义（P =0.001）.其余6个SNP在长寿组和对照组之间差异无统计学意义（均P ＞0.05）.携带风险等位基因s1800796位点的CT单倍型与长寿之间有正相关关系（Padd=0.002,OR=1.983,95％CI：1.296 ～ 3.023）,而其余单倍型与长寿没有显著关联.结论 IL-6基因的rs1800796位点多态可能与新疆维吾尔族自然长寿有关,IL-6基因rs1800796位点CT基因型与长寿有显著关系,C等位基因可能是长寿的不利因素.Objective To investigate whether the variations of genes encoding pro-inflammatory cytokines is associated with longevity in Uyghurs in Xinjiang.Methods A total of 240 individuals aged ≥ 90 years from Xinjiang Uyghur Autonomous Region were enrolled between 1999 and 2012 as the longevity group,92 unrelated individuals from the same area who died naturally at the age of 59-73 in the same period were selected as the control group.Seven single nucleotide polymorphisms （SNPs） of 4 genes （tumor necrosis factor （TNF）-α （rs1800629）,IL-6 （rs1800796,rs10499563）,C-reactive protein （CRP） （rs2808630,rs1205） and IL-1 3 （rs1143623,rs16944）） were genotyped.Logistic regression was applied to assess the association between each individual SNP and longevity in case-control analyses.Results The distribution of C allele of rs1800796 in the longevity group （0.298） was lower than that in the control group （0.435） with statistical significance （P =0.001）.The distributions of the other 6 genetic variations between the longevity group and the control group showed no statistically significant differences （all P 〉 0.05）.CT genotype of rs1800796 was positively associated with longevity （Padd =0.002,OR =1.983,95% CI：1.296-3.023）,while no significant association was noted between other genotypes and longevity.Conclusions SNP of rs1800796 of IL-6 gene may be significantly associated with longevity in Uyghurs in Xinjiang.CT genotype of rs1800796 is significantly associated with longevity.C allele of rs1800796 may be a negative factor for longevity.

关 键 词：长寿 白细胞介素6 多态性 单核苷酸 INTERLEUKIN-6 

分 类 号：R195[医药卫生—卫生统计学]