阿托伐他汀对老年冠心病患者同型半胱氨酸和内皮功能的影响  

Effects of atorvastation on homocysteine and endothelial function in elderly patients with coronary heart disease

作　　者：祝春华[1] 张严高[1] 

机构地区：[1]南京军区杭州疗养院,杭州310007

出　　处：《江西医药》2015年第10期996-998,共3页Jiangxi Medical Journal

摘　　要：目的探讨阿托伐他汀对老年冠心病患者同型半胱氨酸(homocysteine,Hcy)和血清一氧化氮(nitric oxide,NO)、血浆内皮素(endothelin,ET)的影响。方法选取2012年1月至2013年6月我院收治的老年冠心病患者220例,随机分为对照组和治疗组各110例,两组均按冠心病常规内科治疗,治疗组加用阿托伐他汀20mg/d口服,比较治疗前后两组患者血脂、同型半胱氨酸(Hcy)、一氧化氮(NO)、内皮素(ET)的变化。结果经过12周的治疗,治疗组的TC、TG、LDL-C、Hcy、ET显著降低,而HDL-C、NO升高,差异有统计学意义(P<0.05)。结论阿托伐他汀能有效降低老年冠心病患者的TC、TG、LDL-C、Hcy、ET水平,升高HDL-C、NO水平,对预防动脉粥样硬化的发生、发展和改善内皮功能有重要意义。Objective To explore the effect of atorvastation on homocysteine and endothelial function in elderly patients with coronary heart disease. Methods Two hundred and twenty elderly patients with coronary heart diease from January 2012 to June2013 were assigned randomly into two groups：treatment group（n=110） and control group（n=110）,All patients were given conventional treatment,and the treatment group was added with atorvastation 20mg/d. The changes of blood lipid、homocysteine、endothelin and nitric oxide of two groups were compared before and after treatment. Results After 12 weeks of treatment,the TC and TG and LDL-C and Hcy and ET of treatment group were significantly lower,and HDL-C,NO were significantly higher（P〈0.05）.Conclusion Atorvastation can reduce the level of TC,TG,LDL-C,Hcy,ET and improve the level of HDL-C,NO effectively in elderly patients with coronary heart disease,and was useful for the prevention of development and progress of atherosclerosis and improve the function of vascular endothelium.

关 键 词：阿托伐他汀 冠心病 同型半胱氨酸 内皮功能 

分 类 号：R541.4[医药卫生—心血管疾病]