颈部低度迷走神经刺激对老年房颤患者血清CRP、TNF-α及MMP-9/TIMP-1水平的影响  

Effect of Low Degree Vagus Nerve Stimulation on the Levels of TNF-α,CRP and MMP-9/TIMP-1 in Elderly Patients with Atrial Fibrillation

作　　者：李朋[1] 李睿[1] 胡威[1] 徐业成[1] 王丹丹[1] 李屏[1] 杨海珍[1] 

机构地区：[1]华中科技大学同济医学院附属孝感医院心血管内科,湖北孝感432000

出　　处：《现代生物医学进展》2015年第33期6476-6479,共4页Progress in Modern Biomedicine

基　　金：湖北省自然科学基金项目(2011CDB315)

摘　　要：目的:探讨颈部低度迷走神经刺激对老年房颤患者血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶抑制剂-1(TIMP-1)的影响。方法:选取我院收治的老年房颤患者126例,根据治疗方法的不同分为两组。对照组63例,予常规治疗,日1次,7天为1个疗程,治疗2个疗程;实验组63例,在对照组的基础上加以颈部低度迷走神经刺激术。治疗后,观察并比较两组患者的CRP、TNF-α及MMP-9、TIMP-1的变化情况。结果:治疗后,两组患者的血清CRP、TNF-α、MMP-9及TIMP-1均较治疗前显著降低,且实验组显著低于对照组,差异均有统计学意义(P<0.05)。实验组治疗后6个月内房颤的发生率显著降低,差异均有统计学意义(P<0.05)。结论:颈部低度迷走神经刺激能够有效降低老年房颤患者的复发率,这可能与其降低血清CRP、TNF-α,MMP-9、TIMP-1的水平有关。Objective： To investigate the effect of low degree vagus nerve stimulation on the serum TNF-α, CRP and MMP-9/TIMP-1 levels in elderly patients with atrial fibrillation. Methods： 126 elderly patients with atrial fibrillation admitted in our hospital were selected and divided into the control group （63 cases） and the experimental group （63 cases） by different treatment. The control group was treated by conventional therapy and the experiment group was treated on the base of the control group with the low degree vagus nerve stimulation. The changes of serum CRP, TNF-α, MMP-9 and TIMP-1 levels were observed and compared after treatment between two groups. Results： Compared with the control group, the serum CRP and TNF-α levels were lower （P〈0.05）; the TIMP-1 and MMP-9 expressions were lower （P 〈0.05）. The incidence of atrial fibrillation in experimental group was significantly decreased after 6 months of treatment （P〈0.05）. Conclusion： Low degree of cervical vagus nerve stimulation could affect the changes of serum CRP, MMP-9, TNF- and TIMP-1 in elderly patients with atrial fibrillation, and significantly reduce the incidence of atrial fibrillation, which was worthy of clinical application.

关 键 词：迷走神经刺激 房颤 C反应蛋白 肿瘤坏死因子-α 基质金属蛋白酶-9 

分 类 号：R541.75[医药卫生—心血管疾病]