环境光导致昼夜节律紊乱对睡眠的影响  

The Effects of Circadian Disruption by Environmental Light on Sleep

作　　者：陈钧 杜莉[2] 王佩 魏虹 韩祖成 

机构地区：[1]陕西省中医医院脑病科,陕西西安710000 [2]河南大学第一附属医院儿科,河南开封475000

出　　处：《现代生物医学进展》2015年第31期6046-6049,6115,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81402055)

摘　　要：目的:研究通过环境光扰乱正常昼夜节律对睡眠的影响。方法:使用小鼠昼夜节律模型(20小时一个循环,10小时见光,10小时避光),利用小鼠睡眠生物解析系统,记录脑电波和肌电波,分析睡眠觉醒量、不同时间睡眠觉醒波delta功率和睡眠时相转换等参数。结果:昼夜节律干扰后导致昼夜觉醒差异、非快速眼动睡眠差异(NREM),和快速眼动睡眠(REM)差异消失(P>0.05),昼夜节律干扰后增加了觉醒和NREM睡眠之间的转换次数(P<0.05),昼夜节律紊乱的光照时相在开始时没有delta功率减弱征象(P>0.05)。结论:昼夜节律模型不会导致典型的睡眠剥夺,但是会对睡眠时间和质量会产生影响。本研究一步证实昼夜节律对睡眠调节有着重要的作用。Objective： To study the effects of circadian disruption by environmental light on sleep. Methods： Disrupting the circadian clock by altered light-dark cycles（a shortened 20 h day, 10 h light, 10 h dark;LD10：10）, we used mouse sleeping analysis system to record electroencephalogram and electromyogram, to analyze sleeping and awaking time in a day, delta power of sleeping and awaking waves in different time,and times of sleeping and awaking switchover. Results： Environmental circadian disruption by light caused loss of normal day-night differences in wake, non-rapid eye movement sleep（NREM）, and rapid eye movement sleep（REM）（P〉 0.05） between light and dark phases. Circadian disruption increased the number of transitions between wake and NREM（P〈0.05）. Environmental circadian disruption by light abolished the normally observed decrease in delta power at the onset of the light phase（P〈0.05）. Conclusion：Our results demonstrate that this model of circadian disruption did not lead to marked sleep deprivation, but instead affected the timing and quality of sleep.

关 键 词：昼夜节律 睡眠觉醒 非快速动眼睡眠 快速动眼睡眠 

分 类 号：Q63[生物学—生物物理学] Q428