连续肾脏替代治疗对脓毒症患者血清中TNF-α、IL-6和IL-8表达的影响  

Influence of Continuous Renal Replacement Therapy on TNF-α, IL-6 and IL-8 Levels in Sepsis Patients

作　　者：王健[1] 王君[2] 应伟[3] 王静[1] 何帆[1] 

机构地区：[1]广安市人民医院重症医学科,四川广安638000 [2]广安市人民医院医务科,四川广安638000 [3]广安市人民医院肿瘤科,四川广安638000

出　　处：《现代生物医学进展》2015年第31期6119-6121,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨连续肾脏替代治疗(CRRT)对脓毒症患者血清中肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)和白介素-8(IL-8)的影响。方法:将我院2013年1月-2014年6月间收治的80例脓毒症患者随机分为观察组与对照组各40例,两组患者均给予脓毒症常规治疗,观察组另给予CRRT治疗。观察比较两组患者治疗前1天,治疗后24 h,72 h空腹静脉血TNF-α、IL-6、IL-8水平。结果:观察组治愈率为85.0%(34/40),明显高于对照组的55.0%(22/40),差异有统计学意义(P<0.05);治疗24h、72h后两组患者TNF-α、IL-6和IL-8水平均明显下降,其中观察组下降更显著,差异均有统计学意义(P<0.05)。结论:CRRT能有效降低脓毒症患者血清中TNF-α、IL-6和IL-8水平,有助于对炎症反应的正向调节。Objective： To explore the influence of continuous renal replacement therapy（CRRT） on TNF-α, IL-6 and IL-8 levels in sepsis patients. Methods： 80 sepsis patients who treated in our hospital from January 2013 to June 2014 were randomly divided into observer group and control group, each with 40 patients. The two groups were treated with conventional sepsis therapy, while the observer group was added with CRRT. Compared the curative effect in two groups and the TNF-α, IL-6 and IL-8 levels in 1 day before treatment,24 h and 72 h after treatment. Results： The cure rate of observer group was 85%（34/40）, which was significantly higher than 55%（22/40）in the control group, the difference was statistically significant（P〈0.05）; TNF-α, IL-6 and IL-8 levels of two groups significantly decreased 24 h and 72 h after treatment, but the observer group decreased more, the differences were statistically significant（P〈0.05）.Conclusion： CRRT could effectively reduce TNF-α, IL-6 and IL-8 levels in sepsis patients and make a positive regulator in inflammatory responses.

关 键 词：连续肾脏替代治疗 脓毒症 细胞因子 肿瘤坏死因子Α 白介素-6 白介素-8 

分 类 号：R631.2[医药卫生—外科学]