二甲双胍抗肿瘤作用及其分子机制的研究进展  

The Antitumor Effects of Metformin and the Underlying Molecular Mechanisms

作　　者：胡俊锋[1] 张先娇[2] 王沛侠 郑达鑫 李连香[2] 江欣 张磊[4] 罗苗[4] 史美娜[4] 秦绪军[4] 王枫[4] 刘寒强[4] 

机构地区：[1]第四军医大学本科学员1旅,陕西西安710032 [2]陕西省人民医院,陕西西安710068 [3]陕西省长安医院健康管理中心,陕西西安710016 [4]第四军医大学军事预防医学系营养与食品卫生学教研室,陕西西安710032

出　　处：《现代生物医学进展》2015年第31期6166-6170,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81201928)

摘　　要：二甲双胍是全球范围内治疗2型糖尿病最常用的药物之一,具有使用方便、疗效好、价格低廉且毒副作用小等优点。近年来大量的流行病学研究及体内外实验研究发现二甲双胍能够用于多种肿瘤的治疗及预防,然而其分子机制尚不十分明确;主要包括调节体内胰岛素/IGF-1轴、激活AMPK信号通路、调控micro RNAs的表达、活化Caspase分子、阻断AGEs-RAGE系统等,这些机制为将来二甲双胍应用于肿瘤的预防及临床治疗提供了重要的理论依据。本文针对糖尿病治疗药物二甲双胍在抗肿瘤中的作用及其分子机制进行全面综述。Metformin is one of the most commonly used drugs for the treatment of type 2 diabetes（T2DM）, with the advantages of convenient use, good efficacy, safety, inexpensive and small side effects. Epidemiological studies suggest that metformin may reduce the cancer risks and overall cancer mortality. Recent studies in vitro and in vivo indicate that metformin inhibits cancer cell growth and reduces cancer risk. However, the molecular mechanisms underlying its effects on cancer are not clear yet, mainly including insulin-IGF axis, AMPK pathway, regulation of micro RNAs expression, caspase family activation, blockage of AGE-RAGE system, and et al. These molecular mechanisms may provide an important theoretical basis for metformin to prevent and treat cancer in the future. Here, we pooled data currently available to comprehensively review the antitumor effects and the molecular mechanisms of metformin, an antidiabetic drug.

关 键 词：二甲双胍 糖尿病 肿瘤 分子机制 

分 类 号：R730.5[医药卫生—肿瘤]