C-反应蛋白和胱抑素C联合检测诊断痛风患者早期肾功能损伤的临床分析  

C-reactive Protein and Cystatin C combined Detection of Clinical Analysis in the Diagnosis of Early Renal Damage in Patients with Gout

作　　者：丁弘[1] 朱进华[1] 田英[1] 宋磊[1] 

机构地区：[1]江苏省扬中市人民医院肾脏科,江苏扬中212200

出　　处：《中国医药指南》2015年第32期25-26,共2页Guide of China Medicine

摘　　要：目的探讨C-反应蛋白和胱抑素C联合检测诊断痛风患者早期肾功能损伤的临床效果。方法回顾性分析本院2014年6月至2015年6月收治的61例痛风患者的临床资料,按照是否合并早期肾功能损伤分为对照组(30例,未合并)和观察组(31例,合并)。检测两组的C-反应蛋白和胱抑素C,进行比较。并对观察组患者分别进行C-反应蛋白检测、胱抑素C检测和C-反应蛋白+胱抑素C检测,观察三种检测方法的阳性率,并进行比较。结果经检测和比较,观察组的C-反应蛋白和胱抑素C检测水平均显著高于对照组,经比较差异均有统计学意义,均P<0.05,经不同的检测,观察组患者予以单纯C-反应蛋白检测和胱抑素C检测的阳性率均显著低于C-反应蛋白+胱抑素C检测,均P<0.05;单纯C-反应蛋白检测的阳性率低于胱抑素C检测,但经比较差异无统计学意义,P>0.05。结论较之单纯C-反应蛋白、胱抑素C检测,对痛风患者予以C-反应蛋白和胱抑素C联合检测可以达到较高的早期肾功能损伤阳性检出率。Objective To explore the effect of C- reactive protein and cystatin C combined detection in the diagnosis of the clinical effect of early renal damage in patients with gout. Method A retrospective analysis was performed on clinical data of 61 patients with gout in our hospital from June 2014 to June 2015, and were divided into control group （30 cases, not complicated） and observation group （31 eases, combined） according to whether or not the early renal damage. Detection of C- reactive protein and cystatin C in two groups were compared. And to the patients in the observation group were the detection of C-reactive protein and cystatin C detection and C-reactive protein and cystatin C detection to observe the positive rate of three kinds of detection methods, and compared. Results After testing and comparison, the observation group of C-reactive protein and cystatin C detection level was significantly higher than that in the control group, to compare the differences were statistically significant （allP〈0.05）. The detection of different observed group of patients to be pure C-reactive protein detection and cystatin C detection positive rate were significantly lower than the detection of C-reactive protein and cystatin C （all P〈0.05）; pure C-reactive protein detection experimental rate lower than the detection of cystatin C, but the difference no statistical significance （P〉0.05）. Conclusion Compared with the simple C - reactive protein, Cystatin C detection. For patients with gout be combined detection of C-reactive protein and cystatin C can reach higher early renal function injury positive rate.

关 键 词：痛风 早期肾功能损伤 C-反应蛋白 胱抑素C 联合检测 

分 类 号：R589.7[医药卫生—内分泌]