β-hCG、孕酮在监测输卵管妊娠保守治疗中的变化研究  

Serum β-h CG and progesterone changes in monitoring medical conservative treatment of tubal pregnancy

作　　者：汤素文 

机构地区：[1]广州市天河区人民医院,广州510660

出　　处：《临床医学》2015年第10期8-11,共4页Clinical Medicine

摘　　要：目的观察β-人绒毛膜促性腺激素（β-h CG）、孕酮用于监测输卵管妊娠保守治疗中的变化情况,探讨各观察指标与治疗效果的相关性和输卵管妊娠保守治疗的预测指标。方法选择异位妊娠病例120例,不限制血清β-h CG值、孕酮值,排除出血性休克者均予药物保守治疗。统一药物保守治疗方案,甲氨蝶呤20 mg肌肉注射,每天1次,连续5 d;随机选择联合米非司酮（米非司酮25 mg口服,每天2次,共3 d）、复方米非司酮（米非司酮30 mg＋双炔失碳酯5 mg口服,每天1次,共2 d）及单纯使用甲氨蝶呤。治疗第1、4、7、11、14天分别用化学发光法检测血清β-h CG值、孕酮值。结果β-h CG值最能反映治疗结局及住院天数的预测性;第4-7天孕酮变化较孕酮第1-4天的变化更有意义。结论动态观察β-h CG值、孕酮能加强异位妊娠结果的预测。Objective To observe the changes of serum β-h CG and progesterone in the medical conservative treatment of tubal pregnancy,and investigate the correlation of each observation index with treatment effects,and the indexes of forecasting the medical conservative treatment of tubal pregnancy. Methods A total of 120 ectopic pregnancy patients were selected and the levels of serum β-h CG and progesterone were unlimited. All cases were given conservative treatment with medication except patients with hemorrhagic shock. All patients were treated with methotrexate（ MTX 20 mg / d,i. m,5 days）,and followed by mifepristone（ 50 mg each time,twice-daily for three days）,compound mifepristone（ one pill orally,once a day,for 2 days） and the simple use of methotrexate. The serum levels of β-h CG and progesterone were detected on day 1,4,7,11,and 14 after the therapy. Results β-h CG value can reflect the treatment effect and the predictability of the length of hospital stay; compared with the day 4 to 7 of the level of serum progesterone,the changes of the serum progesterone day 1 to 4 were more meaningful.Conclusion Dynamic observation of β-h CG and progesterone value can improve the prediction of ectopic pregnancy outcome.

关 键 词：输卵管妊娠 Β-人绒毛膜促性腺激素 孕酮 

分 类 号：R714.22[医药卫生—妇产科学]