燃煤型氟中毒病区8～14岁儿童血清Ⅰ型胶原交联氨基末端肽的浓度变化  

Serum N-telopeptide of type Ⅰ collagen levels in children aged 8-14 in coal-burning type fluorosis area

作　　者：金庭旭[1] 吴延莉 韦艳[1] 谢春[1] 张华[1] 

机构地区：[1]贵州医科大学公共卫生学院环境卫生学教研室,贵州贵阳550025

出　　处：《环境与健康杂志》2015年第8期688-690,共3页Journal of Environment and Health

基　　金：科技部国家科技支撑计划课题(2013BAI05B03);国家自然科学基金(81360412)

摘　　要：目的探讨燃煤型氟中毒病区8～14岁儿童血清Ⅰ型胶原交联氨基末端肽（NTx）的浓度变化及其与年龄、氟斑牙程度的关系,为氟中毒骨性损伤研究提供人群数据资料。方法于2013年9月对贵州省187名8～14岁儿童（包括地方性氟中毒病区123人,对照区64人）进行氟斑牙诊断,并测定血清NTx浓度,分析病区不同氟斑牙程度的儿童血清NTx浓度变化及其与年龄、氟斑牙程度的相关性。结果燃煤型氟中毒病区儿童氟斑牙患病率为94.3%,高于对照区,差异有统计学意义（P〈0.01）;血清NTx浓度差异无统计学意义（P〉0.05）。各年龄组病区儿童氟斑牙患病率均高于对照区,13～14岁病区儿童血清NTx浓度低于对照区,差异均有统计学意义（P〈0.01）。氟斑牙轻度和中度组儿童的血清NTx浓度低于未患病和极轻度组,差异有统计学意义（P〈0.05）。氟斑牙程度与年龄呈正相关（rs=0.377,P〈0.05）,与血清NTx浓度呈负相关（rs=-0.510,P〈0.05）,而血清NTx浓度与年龄无相关性（rs=-0.147,P〉0.05）。结论过量的氟可能导致儿童血清NTx浓度降低,但其剂量-效应关系有待明确。Objective To investigate the relationship betweenn age,levels of dental fluorosis and serum N-telopeptide of typeⅠcollagen（NTx） metabolism in children aged 8-14 in coal-burning fluorosis area. Methods A cross-sectional study was used to investigate the prevalence of dental fluorosis and serum NTx metabolism of 187 children aged 8-14 in Sep., 2013.The difference of serum NTx in children between the endemic area and the control area and the changes of children ＇s serum NTx levels with different levels of dental fluorosis were analyzed. Results The prevalence rate of dental fluorosis of children in endemic area was 94.3%, which was significantly higher than control（P〈0.01）. However, the difference of serum NTx levels had no statistical significance（P〈0.05）. The prevalence rate of dental fluorosis in endemic area was higher than control in each age groups, but the serum NTx which was lower than control only showed a statistically significant in the 13-14 age group（ P〈0.01）. The results of children＇s serum NTx levels with different levels of showed that the serum NTx levels of children with mild and severe dental fluorosis were lower than those with extremely mild dental fluorosis or without dental fluorosis. The degree of dental fluorosis positively correlated with age（rs=0.377,P 〈0.05） and negatively correlated with serum NTx levels（rs=-0.510, P〈0.05）. Conclusion High fluoride exposure can cause the change of serum NTx metabolism in children, but the dose-effect relation is not known.

关 键 词：燃煤型氟中毒 儿童 Ⅰ型胶原交联氨基末端肽 

分 类 号：R181.3[医药卫生—流行病学]