氯吡格雷联合常规治疗急性心绞痛166例临床观察  

Clinical efficacy of clopidogrel combined with conventional therapy in treatment of acute angina: an analysis of 166 cases

作　　者：徐东[1] 王宏军[1] 郝刚[1] 

机构地区：[1]黑龙江省哈尔滨市第一医院,黑龙江哈尔滨150010

出　　处：《心血管病防治知识（学术版）》2015年第11期42-44,共3页Prevention and Treatment of Cardiovascular Disease

摘　　要：目的探讨氯吡格雷联合常规治疗急性心绞痛的临床疗效。方法选取2013年8月~2015年8月我院接诊的急性心绞痛患者166例,随机分为对照组（n=83）与实验组（n=83）,对照组接受常规治疗,实验组接受常规治疗＋氯吡格雷治疗。分析比较两种治疗方案的临床效果。结果治疗前,实验组心绞痛每日发作频率及持续时间均与对照组相当,差异均无统计学意义（P〉0.05）。治疗后,心绞痛发作频率：实验组为（1.01±0.21）次/d,对照组为（1.96±0.75）次/d,组间差异有统计学意义（P〈0.05）;发作持续时间：实验组为（3.17±1.14）min,对照组为（5.73±1.25）min,组间差异有统计学意义（P〈0.05）。治疗总有效率：实验组为95.18%,对照组为81.93%,组间差异有统计学意义（P〈0.05）。结论氯吡格雷联合常规治疗可减少患者心绞痛发作频率,缓解病痛,医疗作用明显,值得推广应用。Objective To investigate the clinical efficacy of clopidogrel combined with conventional therapy in the treatment of acute angina. Methods A total of 166 patients with acute angina who were treated in our hospital from August 2013 to August 2015 were selected and randomized into control group（n=83） and experiment group（n=83）. The patients in control group were given conventional therapy, and those in the experiment group were given conventional therapy combined with clopidogrel. The clinical effects of these two regimens were analyzed and compared. Results Before treatment, the two groups had comparable daily frequency and duration of angina attacks,without significant difference between the two groups（P 0.05）. After the treatment, the experiment group and the control group had frequencies of angina attacks of（1.01 ±0.21） and（1.96 ±0.75） times/day, respectively, with a significant difference between the two groups（P0.05）; the durations of attacks in the experiment group and the control group were（3.17±1.14） and（5.73±1.25） min, respectively, with a significant difference between the two groups（P0.05）. The experiment group had an overall response rate of 95.18%, while the control group had an overall response rate of 81.93%, with a significant difference between the two groups（P0.05）. Conclusion Clopidogrel combined with conventional therapy can reduce the frequency of angina attacks and relieve pain, and is worthy of clinical application.

关 键 词：急性心绞痛 氯吡格雷 疗效 

分 类 号：R541.4[医药卫生—心血管疾病]