地尔硫与西酞普兰联用致老年患者QT间期延长2例  

QT interval prolongation induced by citalopram and diltiazem in two elderly patients

作　　者：侯晓平[1] 魏璇[1] 

机构地区：[1]空军总医院干部病房,北京100142

出　　处：《药物不良反应杂志》2015年第5期371-372,共2页Adverse Drug Reactions Journal

摘　　要：2例冠状动脉粥样硬化性心脏病合并抑郁症的老年患者（例1男，90岁；例2女63岁）长期服用西酞普兰（20 mg/d；分别为4和1年），用药期间心电图QT间期正常。因心绞痛反复发作，男性患者服用地尔硫15 mg、3次/d，女性患者服用地尔硫30 mg、3次/d，分别于用药4 d和83 d行心电图检查发现QT间期延长，QT间期/校正QT间期（QT/QTc）分别为448/526 ms和430/447 ms。男性患者停服地尔硫5 d后QT/QTc为 432/510 ms，女性患者将地尔硫减半量35 d后心电图检查示QT/QTc为388/406 ms。Two elderly patients （one was male, 90 years-old; the other female, 63 years-old） with coronary disease and depression received citalopram 20 mg daily for 4 years and 1 year, respectively. The width of their electrocardiogram QT interval was normal. They received diltiazem 15 mg three times daily （the male） and 30 mg three times daily （the female） due to recurrent attacks of angina pectoris. QT interval prolongation was found by electrocardiographic examination on day 4 （the male） and day 83 （the female） of medication with diltiazem, the QT interval/corrected QT interval（QT/QTc） were 448/526 ms （the male） and 430/447 ms （the female）, respectively. The QT/QTc in the male patient decreased to 432/510 ms 5 days after diltiazem withdrawal. The QT/QTc in the female patient decreased to 388/406 ms on 35 days after diltiazem＇s dosage was halved.

关 键 词：西酞普兰 地尔硫 QT延长综合征 

分 类 号：R540.41[医药卫生—心血管疾病]