羟氯喹致荨麻疹型药疹  

Urticarial eruption induced by hydroxychloroquine

作　　者：赵义[1] 黄旭[1] 李小霞[1] 

机构地区：[1]首都医科大学宣武医院风湿免疫科,北京100053

出　　处：《药物不良反应杂志》2015年第5期379-380,共2页Adverse Drug Reactions Journal

摘　　要：1例28岁女性系统性红斑狼疮患者在服用泼尼松、羟氯喹、来氟米特、碳酸钙D3及塞来昔布后1个月出现全身瘙痒、颜面水肿及泛发性荨麻疹型皮疹，停用所有药物并给予甲泼尼龙、依巴斯汀、西替利嗪抗过敏治疗2周，皮疹完全消退。但再次服用羟氯喹1周后又出现全身瘙痒，停药后症状消失。此后再次给予来氟米特、骨化三醇及碳酸钙D3口服，患者未再出现皮疹。A 28-year-old female patient with systemic lupus erythematosus received treatments with prednisone, hydroxychloroquine, leflunomide, calcium carbonate D3, and celecoxib. After 1 month of treatments, she developed itching over whole body, edema of eyelids and face, and generalized urticarial eruption. All drugs were discontinued and methylprednisolone, ebastine, and cetirizine hydrochloride were given. Two weeks later, skin rashes completely disappeared. However, the itching appeared again when the patient was given hydroxychloroquine treatment again for 1 week and disappeared after the drug withdrawal. After that, leflunomide, calcitriol, and calcium carbonate D3 were given again and no rashes recurred.

关 键 词：羟氯喹 药疹 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]