误服大剂量水合氯醛致新生儿呼吸暂停  

Apnea in a neonate due to mistaken high-dose chloral hydrate

作　　者：李英[1] 刘莹[1] 史强[1] 王晓玲[1] 

机构地区：[1]首都医科大学附属北京儿童医院药学部,100045

出　　处：《药物不良反应杂志》2015年第5期395-396,共2页Adverse Drug Reactions Journal

基　　金：中国/世界卫生组织2014.2015双年度合作项目（WPCHN1408195,5.1,61775）

摘　　要：1例25日龄男性新生儿因疑诊先天性心脏病欲行心脏超声检查，医师开具水合氯醛合剂10 ml，注明检查前口服2 ml。患儿家长取药时药师仅口头交代给患儿口服2 ml，而未书面标明用法用量。检查前，患儿家长将10 ml水合氯醛全部给患儿服下，导致患儿在超声检查期间出现呼吸暂停。给予气管插管及静脉滴注氨茶碱。次日改为鼻导管吸氧。6 d后，患儿病情好转。A 25-day-old male neonate suspected of having congenital heart disease underwent echocardiographic examination. The physician prescribed chloral hydrate mixture 10 ml, oral 2 ml before the examination. The pharmacist just told to take 2 ml, without written dosage indication. Before the ultrasound examination, the parent administered the newborn 10 ml chloral hydrate mixture, and then, he developed apnea during the examination. He received tracheal intubation and intravenous infusion of aminophylline. The next day, he was given oxygen inhalation through nasal tube. Six days later, the infant＇s condition was improved.

关 键 词：水合氯醛 给药错误 婴儿  新生 

分 类 号：R722.1[医药卫生—儿科]