老年人亚临床甲状腺机能减退与动脉硬化相关危险因素的关系研究  

Relationship between subclinical hypothyroidism and atherosclerosis related risk factors in a senile population

作　　者：左曼军[1] 魏鸿[1] 

机构地区：[1]福建省立医院干二科

出　　处：《老年医学与保健》2015年第5期290-292,共3页Geriatrics & Health Care

摘　　要：目的探讨老年人亚临床甲状腺机能减退症（SCH）与动脉硬化相关危险因素的关系。方法选取老年SCH患者65例作为观察组，并设对照组42例，分析比较2组体质指数，血压水平，血糖，糖化血红蛋白，血脂全套，高敏C反应蛋白（hs-CRP），同型半胱氨酸（Hcy）。结果与对照组相比，观察组总胆固醇及低密度脂蛋白胆固醇均明显增高（P〈0．05）；hs-CRP亦显著增高（P〈0．05），Hcy水平增高更为明显（P〈0．01）。结论老年SCH患者存在血脂紊乱、高C反应蛋白水平、高同型半胱氨酸血症，提示老年SCH患者存在更明显的动脉硬化病理生理基础，可能预示有更高的心、脑血管疾病的风险。Objectives To explore the relationship between subclinical hypothyroidism （SCH） and the relative risk fac- tors of atherosclerosis （AS） in a senile population. Methods 65 elderly patients with SCH （TSH≥4.12 mIu/L）and 42 out- patients（TSH≤4.12 mIu/L）were selected as observation group and control group. Body mass index,blood pressure, glucose, glycasted hemoglobin, lipids, highly sensitive highly sensitive C reactive protein（hs-CRP）, homocysteine （Hcy） were analy- sised between two groups. Results Compared with the control group, elevated total cholesterol （TC） （P〈 0.005）, lowered density lipoprotein-cholesterol （LDL-C） levels （P〈 0.005）, elevated hs-CRP levels （P〈 0.005）, were found in SCH groups. Compared with the control group, more obviously elevated Hcy levels （P〈 0.01） were found in SCH groups. Conclusions The phenomenon of lipids abnormality, high C reactive protein levels and hyperhomocystinemia were found in senile SCH patients. More noticeable Pathophysiologicallyatherosclerosis were found in senile SCH patients, which may indicate this group are under higher risk of developing cardiovascular and cerebrovascular disease.

关 键 词：亚临床甲状腺机能减退 症动脉硬化 C-反应蛋白 同型半胱氨酸 

分 类 号：R581.2[医药卫生—内分泌]