甲泼尼龙不同给药方式治疗突发性感音神经性聋的疗效观察  

The efficacy of different administration modes of methylprednisolone on idiopathic sudden sensorineural hearing loss

作　　者：姜凤举 彭裕萍 李艳[1] 申江江 王利亚[2] 

机构地区：[1]榆林市第一医院耳鼻喉科,陕西榆林719000 [2]西安交通大学医学院第二附属医院,陕西西安71004

出　　处：《西部医学》2015年第11期1631-1633,共3页Medical Journal of West China

基　　金：国家自然科学基金(81141097)

摘　　要：目的 观察不同给药方式的甲泼尼龙对不同分型特发性突发性感音神经性耳聋（ISSHL）的疗效。方法选取2009年5月~2014年5月的ISSHL患者300例,其中低中频下降型81例,中高频下降型63例,平坦型30例,全聋型126例。随机将患者分为3组,即鼓室给药组（100例）,静脉给药组（100例）,口服给药组（100例）,分析甲泼尼龙三种不同的给药方式对不同类型患者痊愈率与总有效率的影响。结果 鼓室给药组中低中频下降型痊愈率较中高频下降型、全聋型高,差异有统计学意义（P〈0.05）,三种方式比较鼓室内给药组低中频下降型痊愈率比静脉给药组、口服组高差异有统计学意义（P〈0.05）。结论 低中频下降型ISSHL经鼓室内注射甲泼尼龙治疗比静脉注射和口服效果好,其它三型若无激素应用禁忌者,建议可选择全身用药。Objective To assess the efficacy of administration modes of methylprednisolone in treatment of idio- pathic sudden sensorineural hearing loss（ISSHL）. Methods 300 patients with ISSHL, including 81 with hearing loss in low-middle frequencies, 63 in middle-high frequencies, 30 in all frequencies and 63 in total deafness, were divided into In- travenous group（100 ears）, intratympanic injection group（100 ears） and oral group（100 ears）. Results In intratympanic injection group, the recovery rate in low-middle frequencies subgroups was significant higher than that in middle-high （P〈0.05） and all frequencies subgroups（P〈0.05）. The patients of low-middle frequencies with intratympanic injection of methylprednisolone was significant higher than systemic application（P〈 0.05）, and there were no statistical signifi- cances in other three typing groups by intratympanic injection of methylprednisolone when compared with systemic appli- cation. Conclusion Intratympanic injection should be optimization for low-middle frequency type ISSHL. If patients were glucocorticoids-free application, systemic application should be applied for other three typing frequencies.

关 键 词：特发性突发性感音神经性聋 甲泼尼龙 鼓室内给药 

分 类 号：R987[医药卫生—药品]