急性心肌梗死患者CRP及WBC水平与住院死亡的相关性  

Correlation research of CRP and WBC with dead cases in AMI patients after admission to hospital

作　　者：王佟[1] 韩文忠[1] 郭华[1] 宋瑜[2] 

机构地区：[1]沧州市中西医结合医院,河北沧州061001 [2]哈尔滨医科大学,黑龙江哈尔滨150081

出　　处：《西部医学》2015年第11期1644-1646,共3页Medical Journal of West China

基　　金：国家自然科学基金(81100071)

摘　　要：目的 探讨急性心肌梗死（Acute myocardial infarction,AMI）患者入院后C反应蛋白（C-reactionprotein,CRP）及白细胞（White blood cell,WBC）水平与住院期间死亡的相关性。方法 临床纳入首次入院的AMI患者210例,均为我院2010年1月~2014年12月收住的病例。根据患者住院期间有无发生死亡进行临床分组,采用Logistic回归模型,分析AMI患者入院时CRP与WBC水平与住院期间患者死亡的关联。结果 单因素分析显示,CRP与WBC水平是导致AMI患者住院期间死亡的高危因素（P〈0.05）;因素Logistic回归分析示：CRP与WBC计数处于最高分位组的AMI患者发生研究结局的危险性分别是最低分位组的2.750以及3.278倍（P〈0.05）;经过多因素调整（包括性别、年龄等）后,与最低分位组比较,CRP与WBC水平处于最高分位组的AMI患者住院期间死亡的危险性分别为最低分位组的1.864以及3.492倍（P〈0.05）;无论是否经过调整,趋势性检验结果均提示,发生研究结局的危险性随着CRP与WBC计数水平的升高而增大。结论 入院前患者CRP与WBC升高,能够显著增加AMI患者入院期间的死亡率。Objective To study the correlation of CRP and WBC levels with dead cases in AMI patients after admission to hospital. Methods 210 AMI patients of being initially admitted to hospital from January 2010 to December 2014 in our hospital were selected. The patients were divided into groups according to the incidence of dead cases in hos- pital. Through Logistic regression model, the correlation of CRP and WBC levels with dead cases in hospital was ana- lyzed. Results Through single factor analysis, CRP and WBC levels were the high risk factors for dead cases in AMI patients in hospital （P〈0.05）; Through Logistic regression analysis, the risk rate of dead cases in AMI patients with highest CRP and WBC levels were 2. 750 and 3. 278 times than that of AMI patients with lowest CRP and WBC levels （P%0.05） ;Through multi-factor adjustments （including gender, age, etc）, the risk rate of dead cases in AMI patients with highest CRP and WBC levels were 1. 864 and 3. 492 times than that of AMI patients with lowest CRP and WBC levels （P〈0.05） ; in any way, the tendency inspection results showed that the risk rate of dead cases was increased with higher CRP and WBC levels. Conclusion Before admission to hospital, the higher CRP and WBC levels will significantly increase the death rate of AMI patients in hospital.

关 键 词：急性心肌梗死 C反应蛋白 白细胞 死亡 关联 

分 类 号：R542.22[医药卫生—心血管疾病]