注射用两性霉素B脂质体致贫血、血小板减少不良反应1例  

One case reports on intravenous domestic liposomal amphotericin B induced anemia and thrombocytopenia

作　　者：颜明明[1] 孙佩男[1] 武卓[1] 张亮[1] 赵晖[1] 钟明康[1] 

机构地区：[1]复旦大学附属华山医院药剂科,上海200040

出　　处：《上海医药》2015年第21期71-72,76,共3页Shanghai Medical & Pharmaceutical Journal

基　　金：2012年上海市科委产学研医项目(12DZ1930402)

摘　　要：20岁女性患者,确诊系统性红斑狼疮4年,口服甲泼尼龙8 mg,qd治疗超过1年。既往无食物、药物过敏史。患者因头痛、发热入院,入院行腰椎穿刺,墨汁染色见新型隐球菌。给予两性霉素B脂质体联合氟胞嘧啶治疗。两性霉素B脂质体用药15 d后,患者出现贫血、血小板降低,血红蛋白最低降至80 g/L,血小板最低降至71×109/L,停药1月余后血小板恢复正常,血红蛋白于1年后恢复正常。A 20-year-old woman was diagnosed as systemic lupus erythematosus 4 years ago, and has orally taken methylprednisolone at 8 mg, qd for more than one year. She has no drug or food hypersensitivity history. She was hospitalized due to headache and fever. Lumbar puncture was preformed to her and ink staining showed an infection ofCryptococcus neoformans. Liposomal amphotericin B combined lfuorocytosine were administered. Anemia and thrombocytopenia appeared in the patient after 15 days of treatment, in which hemoglobin and platelet count declined to 80 g/L and 71×109/L. The platelet count was returned to normal one month after the drug was discontinued and the hemoglobin was recovered to normal after one year.

关 键 词：贫血 血小板减少 两性霉素B脂质体 药品不良反应 

分 类 号：R556[医药卫生—血液循环系统疾病] R558.2[医药卫生—内科学]