microRNAs与组织纤维化关系的研究进展  

Progress of microRNAs and tissue fibrosis

作　　者：赵明明[1] 王海蓉[2] 

机构地区：[1]临沂市沂水中心医院心内科,山东临沂276400 [2]武汉大学中南医院

出　　处：《临床心血管病杂志》2015年第11期1238-1241,共4页Journal of Clinical Cardiology

摘　　要：多种原因如高糖、缺血等,可导致心肌纤维化的发生。纤维化主要与细胞外基质的合成与分解失衡相关,可导致器官功能不全。微小核糖核苷酸(mcroRNA)参与了组织器官纤维化的发生发展,现将其研究进展进行综述。A variety of reasons,such as sugar and ischemia,can lead to the myocardial fibrosis.Fibrosis is associated with the synthesis and decomposition of extracellular matrix and can lead to organ dysfunction.McroRNA involved in the development of tissue fibrosis.Now we review the research progress between microRNAs and tissue fibrosis.

关 键 词：微小核糖核苷酸 纤维化 心肌 

分 类 号：R541.4[医药卫生—心血管疾病]