乳酸左氧氟沙星双敏型眼用即型凝胶的制备及含量测定  

Preparation and assaying of lavofloxacin lactate in situ forming eye gel

作　　者：洪怡[1] 康爽[1] 易蕾[2] 李红燕[1] 薛大权[1] 

机构地区：[1]湖北中医药大学药学院,湖北武汉430065 [2]武汉科技大学附属医院药学部,湖北武汉430060

出　　处：《中国医院药学杂志》2015年第21期1925-1928,共4页Chinese Journal of Hospital Pharmacy

基　　金：湖北省高等学校青年教师深入企业行动计划项目(编号:XD2012245)

摘　　要：目的：研究乳酸左氧氟沙星p H/温度双敏型眼用即型凝胶剂的制备及其含量测定的方法。方法：以泊洛沙姆407和卡波姆940为基质,制作p H/温度双敏型眼用即型凝胶;采用高效液相色谱法测定药物含量。结果：该眼用即型凝胶剂基质最佳组成为0.4%卡波姆940和16%的泊洛沙姆407;乳酸左氧氟沙星在0.010 4~0.093 6 mg·ml-1的范围内呈良好的线性关系,精密度良好,平均回收率为99.21%。结论：乳酸左氧氟沙星双敏型眼用即型凝胶工艺简单,含量测定方法可行。OBJECTIVE To prepare and assay lavofloxacin lactate in situ forming eye gel with p H sensitiveness temperature sensitiveness. METHODS Poloxamer 407 and carbomer 940 were used as materials for eye ge1. HPLC method was established to determine drug content in the gel. RESULTS 16% poloxmar 407 and 0. 4% carbomer 940 were suitable to lavofloxacin lactate in situ forming eye gel. Linear relationship of lavofloxacin lactate was good in concentration range of 0. 010 4- 0. 093 6 mg·ml- 1,precision was well and average recovery was 99. 21%. CONCLUSION The technology of preparation is easy and method of assaying is feasible.

关 键 词：乳酸左氧氟沙星 pH/温度双敏型即型凝胶 制备 含量测定 

分 类 号：R944.9[医药卫生—药剂学]