肉桂活性部位对大鼠凝血功能及血液流变学的影响  

Effects of active parts of Cinnamomum cassia on coagulation function and hemorheology in rats

作　　者：曾俊芬[1] 鲁建武[1] 宋金春[1] 

机构地区：[1]武汉大学人民医院药学部,湖北武汉430060

出　　处：《中国医院药学杂志》2015年第21期1937-1940,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察肉桂不同部位对大鼠凝血功能及血液流变学的影响,并筛选出活性部位。方法:(1)大鼠连续给药1周后检测凝血功能指标。(2)大鼠连续给药8 d,于第7天皮下注射盐酸肾上腺素再施以冰水浸泡制作急性血淤模型大鼠,次日测定血液流变学指标。结果:(1)肉桂石油醚部位与其他部位比较活性最强,与空白组比较能延长大鼠PT、APTT、TT(P<0.05)。(2)肉桂石油醚组能降低大鼠的全血黏度及全血还原黏度(P<0.01),提高红细胞变形指数(P<0.05)。结论:肉桂石油醚部位为活性部位,能延长大鼠凝血时间,降低血液黏度,具有抗凝和活血化淤的功效。OBJECTIVE To observe effects of different fractions of Cinnamomum cassia on coagulation function and hemorheology in rats and screen the active fraction. METHODS Rats were continuously given different fractions of Cinnamomum cassia for 1 week,then coagulation function was observed. Rats were continuously fed with different fractions of Cinnamomum cassia for 8 days,blood-stasis model rats were made by injecting adrenalin hydrochloride and soaking in ice water on the seventh day,then hemorheology index was measured the next day. RESULTS Petroleum ether fraction was more potent than other test samples,which could prolong plasma prothrombin time（ PT）,activate partial thromboplastin time（ APTT） and thrombin time（ TT）（ P〈0. 05）. Petroleum ether fraction could reduce viscosity of whole blood（ P〈0. 01） and increase red cell deformation index（ P〈0. 05）. CONCLUSION Petroleum ether fraction of Cinnamomum cassia is the active fraction,which can resist coagulation and improve hemorheology.

关 键 词：肉桂 活性部位 凝血功能 血液流变学 

分 类 号：R285.5[医药卫生—中药学]